Retrospective Evaluation of Intussusception in Under-Five Children in Nigeria
Beckie Nnenna Tagbo, Jason Mwenda, Christopher Eke, Tagbo Oguonu, Sebastin Ekemze, Uchechukwu Obiora Ezomike, Benedict Edelu, Ogechukwu Amadi, Ifeyinwa Okeke, Okechukwu Ani, Roservelt Okechukwu Nnani, Vina Okafor, Henrietta Uche Okafor, Egbuna Obidike, Emmanuel Abanida, Chris Elemuwa, Toyin Odetunde
Department of Paediatric Surgery, Enugu State University Teaching Hospital, Enugu, Nigeria.
Department of Paediatric Surgery, University of Nigeria Teaching Hospital, Enugu, Nigeria.
Department of Paediatrics, Enugu State University Teaching Hospital, Enugu, Nigeria.
Department of Paediatrics, University of Nigeria Teaching Hospital, Enugu, Nigeria.
Institte of Child Health, University of Nigeria Teaching Hospital, Enugu, Nigeria.
Institute of Child Health and Department of Paediatrics, University of Nigeria Teaching Hospital, Enugu, Nigeria.
National Primary Health Care Development Agency, Federal Ministry of Health, Abuja, Nigeria.
World Health Organization Regional Office for Africa (WHO/AFRO), Brazzaville, Republic of Congo.
DOI: 10.4236/wjv.2014.43015   PDF   HTML     4,123 Downloads   5,541 Views   Citations


Background: Assessment of the safety profile of the new rotavirus vaccines in Africa requires base-line epidemiological data on intussusception. Hence, this study was aimed at describing the prevalence and associated factors of intussusception in under-five children in Enugu, Southeast, Nigeria. Methods: This was a retrospective descriptive study involving the sixty reported cases of intussusception in under-five children admitted in a hospital in Enugu between 2007 and 2012. Cases of intussusception were selected using the Brighton collaboration intussusception working group level I diagnostic criteria. Information sought from the patients’ folders included demographic characteristics and clinical manifestations including history of previous rotavirus vaccination, duration of illness prior to presentation, diarrhoea, vomiting, passage of red currant jelly-like stool, abdominal mass and distension, method of diagnosis, treatment option(s) employed and their outcomes. The data was analyzed using SPSS version 17.0. Results: The majority of the cases were aged less than one year (53; 88.3%) while the average incidence of intussusception was 0.1 per 1000. None of the cases had received rotavirus vaccinations. The common clinical presentations were vomiting, 55 (17.2%), passage of red currant stool 50 (15.6%), fever 50 (15.6%) and abnormal/absent bowel sound 43 (15.9%). Diagnosis was essentially with the aid of abdominal ultrasonography, 38 (63.3%) while surgery (laparotomy) was the treatment of choice in most cases 48 (80.0%). The case fatality rate was 3 (5.0%). Conclusion: None of the cases studied could be directly linked to rotavirus vaccinations. But seasonal peak incidence coincided with rotavirus diarrhea peak incidence. Efforts should be made to institute post-rotavirus vaccine licensure prospective surveillance study in order to fully determine any relationship between rotavirus vaccination and intussusception in Enugu, South east, Nigeria.

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Tagbo, B. , Mwenda, J. , Eke, C. , Oguonu, T. , Ekemze, S. , Ezomike, U. , Edelu, B. , Amadi, O. , Okeke, I. , Ani, O. , Nnani, R. , Okafor, V. , Okafor, H. , Obidike, E. , Abanida, E. , Elemuwa, C. and Odetunde, T. (2014) Retrospective Evaluation of Intussusception in Under-Five Children in Nigeria. World Journal of Vaccines, 4, 123-132. doi: 10.4236/wjv.2014.43015.

Conflicts of Interest

The authors declare no conflicts of interest.


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