Residual Risk of Transmission of HIV and Hepatitis B and C by Blood Transfusion in Bukavu in the Democratic Republic of Congo

Jeff Maotela Kabinda; André Nyandwe Bulabula; Philippe Donnen; Réné Fiasse; Jeff Van den Ende; Daniel Sondag-Thull; Dramaix-Wilmet Michèle

doi:10.4236/ojepi.2014.43021

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Open Journal of Epidemiology > Vol.4 No.3, August 2014

Residual Risk of Transmission of HIV and Hepatitis B and C by Blood Transfusion in Bukavu in the Democratic Republic of Congo ()

Jeff Maotela Kabinda, André Nyandwe Bulabula, Philippe Donnen, Réné Fiasse, Jeff Van den Ende, Daniel Sondag-Thull, Dramaix-Wilmet Michèle

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Catholic University of Bukavu, Bukavu, Congo.
Provincial Blood Transfusion Centre of Bukavu, Bukavu, Congo.

DOI: 10.4236/ojepi.2014.43021 PDF HTML 3,207 Downloads 4,035 Views Citations

Abstract

The aim of this study was to determine the incidence rates of HIV1/2 antibodies, HBV and HCV antibodies among voluntary blood donors and to estimate the residual risk of HIV, HBV and HCV infection among blood donors in Bukavu. We conducted a follow-up cohort study of volunteer blood donors who have made at least two blood donations in Bukavu (DRC) between January 2010 and December 2012. We recorded 2986 volunteer blood donors during the study period. The residual risk of viral transmission associated with the serological window was considered as equals to the incidence rate multiplied by the duration of the serological window period divided by 365. Seroprevalence in volunteer blood donors in Bukavu was 1.1% for HIV 1/2 antibodies, 4.0% for HBs Ag and 2.1% for hepatitis C antibody. The number of conversion between two blood donations (incident cases) were observed is 8, 12 and 37 donors respectively for HIV 1/2, HCV and hepatitis B between 2010 and 2012. Incidence rates reported for 1000 person-years were 11.0 for HIV, 51.7 for HBV and 17.1 for HCV. The residual risk as estimated from the window was 0.6 per 1000 donations or 1/1.515 donations for HIV, 3.1 per 1000 donations or 1/329 for HCV and 7.9 per 1000 donations or 1/126 donations for hepatitis B. The residual risk is high. The screening tests are not enough to ensure safe blood. The reduction of residual risk would be achieved through the effectiveness of preventive measures taken for transfusion chain, before and after the biological qualification of blood donation.

Keywords

Residual Risk, Hepatitis, HIV, Blood Donation

Share and Cite:

Kabinda, J. , Bulabula, A. , Donnen, P. , Fiasse, R. , Ende, J. , Sondag-Thull, D. and Michèle, D. (2014) Residual Risk of Transmission of HIV and Hepatitis B and C by Blood Transfusion in Bukavu in the Democratic Republic of Congo. Open Journal of Epidemiology, 4, 157-163. doi: 10.4236/ojepi.2014.43021.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	UNAIDS (2012) World AIDS Day Report, Genève
[2]	Kra, O., N’Dri, N., Ehui, E. and Ouattara, B. (2007) Prevalence of HBs Antigen in Blood Donors in the Bouaké Regional Centre of Blood Transfusion in 2001. Bulletin de Société Pathologie Exotique, 100, 127-129.
[3]	Batina, A., Kabemba, S. and Malengela, R. (2007) Infectious Markers among Blood Donors in the Democratic Republic of Congo (DRC). Revue Medicale de Bruxelles, 28,145-149.
[4]	Moore A, Herrera, G., Nyamongo, J., Lackritz, E., Granade, T., Nahlen, B., et al. (2001) Estimated Risk of HIV Transmission by Blood Transfusion in Kenya. Lancet, 358, 657-660. http://dx.doi.org/10.1016/S0140-6736(01)05783-X
[5]	Candotti, D., Sarkoclie, F. and Allain, J. (2001) Residual Risk of Transfusion in Ghana. British Journal of Haematology, 113, 37-39. http://dx.doi.org/10.1046/j.1365-2141.2001.02679.x
[6]	Dagnra, A.Y., Prince-David, M., Agbénu, S., Ouro-Akpo, T. and Hounkpati, F. (2002) Prevalence and Risk of HCV Transmission after Detection of HIV and HBV in Blood Donors. Médecine et Maladies Infectieuses, 32, 315-319.
[7]	Allain, J.P., Candotti, D., Soldan, K., Sarkodie, F., Phelps, B., Giachetti, C., et al. (2003) The Risk of Hepatitis B Virus Infection by Transfusion in Kumasi, Ghana. Blood, 101, 2419-2425. http://dx.doi.org/10.1182/blood-2002-04-1084
[8]	Allain, J.P., Owusu-Ofori, S. and Bates, I. (2004) Blood Transfusion in Sub-Saharan Africa. Transfusion Alternatives in Transfusion Medicine, 1, 16-23. http://dx.doi.org/10.1111/j.1778-428X.2004.tb00108.x
[9]	Touré-Fall, A.O., Dièye, T.N.D., Sall, A., Diop, M., Seck, M., Diop, S., Thiam, D. and Diakhaté, L. (2009) Residual Risk of Transmission of HIV and HCV, in Senegalese National Blood Bank from 2003 to 2005. Transfusion Clinique et Biologique, 16, 439-443. http://dx.doi.org/10.1016/j.tracli.2009.09.005
[10]	Pillonel, J., Brouard, C., Laperche, S., Barin, F., Bernillon, P. and de Valk, H. (2009) Quantitative Estimate of the Risk of Blood Donation Contamination by Infectious Agents. Transfusion Clinique et Biologique, 16, 138-145. http://dx.doi.org/10.1016/j.tracli.2009.03.016
[11]	Pillonel, J. and Laperche, S. (2004) Trends in Residual Risk of Transfusion-Transmitted Viral Infections (HIV, HCV, HBV) in France between 1992 and 2002 and Impact of Nucleic Acid Testing. Transfusion Clinique et Biologique, 11, 81-86. http://dx.doi.org/10.1016/j.tracli.2004.02.004
[12]	Lawson-Ayayi, S. and Salmi, L.R. (1997) Transfusion Transmitted Infections and Efficacy of Predonation Blood Donor Selection. Transfusion Clinique et Biologique, 6, 513-521. http://dx.doi.org/10.1016/S1246-7820(97)80076-6
[13]	Barlet, V. (2001) Technological Evolutions in Blood Donation Screening and Their Impact on the Residual Risk. Transfusion Clinique et Biologique, 18, 292-301. http://dx.doi.org/10.1016/j.tracli.2011.02.025
[14]	Courouce, A.M. and Pillonel, J. (1996) Risk of Transfusion-Transmitted Viral Infections. Transfusion Clinique et Biologique, 3, 13-18. http://dx.doi.org/10.1016/S1246-7820(96)80008-5
[15]	Schreiber, G.B., Busch, M.P., Kleinman, S.H. and Korelitz, J.J. (1996) The Risk of Transfusion-Transmitted Viral Infections. New England Journal Medecine, 334, 1685-1690. http://dx.doi.org/10.1056/NEJM199606273342601
[16]	Ouattara, H., Siransy-Bogui, L., Fretzd, C., Diane, K.M., Konate, S., Koidio, A., Minga, K.A., Hyda, J., Koffi-Abe, N., Offoumou, A.M. and Abissey, S. (2006) Residual Risk of HIV, HVB and HCV Transmission by Blood Transfusion between 2002 and 2004 at the Abidjan National Blood Transfusion Center. Transfusion Clinique et Biologique, 13, 242-245. http://dx.doi.org/10.1016/j.tracli.2006.03.015
[17]	CDC (2009) Progress toward Strengthening Blood Transfusion Services 14 Countries, 2003-2007. JAMA, 301, 153-154. http://dx.doi.org/10.1001/jama.301.2.153
[18]	Ségbéna, A.Y., Fétéké, L., Bikandou, B., Awitala, E.J. and Koura, A.G. (2009) Situation and Perspectives of Blood Transfusion in Togo. Transfusion Clinique et Biologique, 16, 460-463. http://dx.doi.org/10.1016/j.tracli.2009.07.002
[19]	Namululi, A.B., Guerrieri, C. and Dramaix, W.M. (2013) Prevalence and Incidence of HIV and Hepatitis B among Blood Donors and Estimated Residual Risk of Transmission of HIV and HBV Virus by Blood Transfusion. A Study at the Provincial General Referee Hospital Bukavu, Democratic Republic of the Congo. Revue d’épidémiologie et de Santé Publique, 61,139-144. http://dx.doi.org/10.1016/j.respe.2012.09.005
[20]	Nébié, K.Y., Olinger, C.M., Kafando, E., Dahourou, H., Diallo, S., et al. (2007) Lack of Knowledge of Blood Donors in Burkina Faso (West Africa); Potential Obstacle to Transfusion Security. Transfusion Clinique et Biologique, 14, 446-452. http://dx.doi.org/10.1016/j.tracli.2007.12.005
[21]	Kabinda, J.M. and Katchunga, B.P. (2010) Viral Hepatitis B and C in Individuals Infected with Human Immunodeficiency Virus in Bukavu (South-Kivu), Democratic Republic of Congo. Journal Africain d'Hépato-Gastroentérologie, 4, 230-235. http://dx.doi.org/10.1007/s12157-010-0204-8
[22]	Le Cosquer, P. (2000) Survey on the Anaesthesists and ICU Doctors Normal Practice on Blood Transfusions and Haemovigilance. Annales Francaises d'Anesthésie et de Réanimation, 19, 485-491. http://dx.doi.org/10.1016/S0750-7658(00)00227-6
[23]	Loua, A., Sow, E.M.L., Magassouba, F.B., Camara, M. and Baldé, M.A. (2004) Evaluation of Residual Infectious Risk among Blood Donors in National Center of Blood Transfusion in Conakry. Transfusion Clinique et Biologique, 11, 98-100. http://dx.doi.org/10.1016/j.tracli.2004.01.004
[24]	Sitas, F., Fleming, A.F. and Morris, J. (1994) Residual Risk of Transmission of HIV through Blood Transfusion in South Africa. South African Medical Journal, 84, 142-144.
[25]	du P. Heyns, A., Benjamin, R.J., Ronel Swanevelder, J.P., Laycock, M.E., Pappalardo, B.L., Crookes, R.L., Wright, D.J. and Busch, M.P. (2006) Prevalence of HIV-1 in Blood Donations Following Implementation of a Structured Blood Safety Policy in South Africa. JAMA, 295, 519-526. http://dx.doi.org/10.1001/jama.295.5.519