Cortex Moutan Inhibits Bladder Cancer Cell Proliferation and Expression of Angiogenic Factors
Mei-Yi Lin, Cheng-Huang Shen, Su-Yin Chiang, Syue-Yi Chen, Yu-Shih Lin, Cheng-Da Hsu
Department of Chinese Medicine Pharmacy, Chiayi Chang Gung Memorial Hospital, Chia-Yi, Taiwan.
Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan Department of Urology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan Department of Chinese Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
DOI: 10.4236/pp.2014.58095   PDF   HTML   XML   3,398 Downloads   4,329 Views   Citations


Metastases are the main cause of death among patients with bladder cancer, which is the second most common malignancy of the genitourinary tract and is highly prevalent in the southwestern region of Taiwan. Angiogenesis plays a critical role in tumor growth and metastasis processes and has relevance in disease recurrence, pelvic lymph node metastasis and poor prognosis. Cancer cells can produce several angiogenesis-stimulating factors involved in vascular growth, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and inflammatory cytokines such as interleukin (IL)-8. Common chemotherapeutic drugs for intravesical instillations usually cause major side effects, including urinary frequency, urinary urgency, cystitis, and hematuria. In order to identify a less cytotoxic therapeutic agent that can inhibit tumor cell proliferation, we examined the traditional Chinese herbal medicine Cortex Moutan—reported to have antibacterial, antiviral, anti-inflammatory, antithrombotic, and antitumor properties—for its effects on bladder cancer cell proliferation and expression of angiogenic factors. Our results revealed that Cortex Moutan exhibited high selectivity in inhibiting the growth of bladder cancer cells and also reduced the expression of angiogenesis-stimulating factors in those cells. Thus, we suggest that Cortex Moutan might be used as a cancer therapy drug for bladder’s intravesical chemotherapy in the future.

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Lin, M. , Shen, C. , Chiang, S. , Chen, S. , Lin, Y. and Hsu, C. (2014) Cortex Moutan Inhibits Bladder Cancer Cell Proliferation and Expression of Angiogenic Factors. Pharmacology & Pharmacy, 5, 846-858. doi: 10.4236/pp.2014.58095.

Conflicts of Interest

The authors declare no conflicts of interest.


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