An Efficient and Rapid Synthesis of 2-amino-4-arylthiazoles Employing Microwave Irradiation in Water

DOI: 10.4236/gsc.2011.12007   PDF   HTML     7,086 Downloads   17,409 Views   Citations


A facile, high yielding green chemical synthetic protocol adaptable to the parallel synthesis of a library of potentially bioactive 2-amino-4-arylthiazoles is reported herein. The methodology involves the condensation of various aracyl bromides with N-arylthioureas under MWI using water as solvent, to yield pure products (81%-97%) in very short reaction times (1-20 min).

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K. Jain, J. Bariwal, M. Kathiravan, V. Raskar, G. Wankhede, N. Londhe and S. Dighe, "An Efficient and Rapid Synthesis of 2-amino-4-arylthiazoles Employing Microwave Irradiation in Water," Green and Sustainable Chemistry, Vol. 1 No. 2, 2011, pp. 35-38. doi: 10.4236/gsc.2011.12007.

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The authors declare no conflicts of interest.


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