Relationship of Serum Leptin, BMI, Waist Circumference and Cholesterol Level among Teenagers in the Gaza Strip


Leptin is one of the best known hormone markers for obesity. There is a limited anthropometric data in the Gaza Strip that reveals and arouses the nutritional status among all age groups especially adolescents aged 15 - 19 years old. The study aimed to assess the effect of Leptin hormone, lipid profiles, Body Mass Index (BMI) and waist circumference among secondary school age students in the Gaza Strip. Methodology: A cross sectional study included 442 cases of teenagers aged 15 - 19 years old from governmental and private schools in the Gaza strip. Blood samples were collected for analysis of Leptin hormone and lipid profile and measuring waist circumference for the teenager. Results: The mean of serum Leptin was (28.7) higher among cases than controls (28.1), but it was statistically insignificant (P = 0.85). It was found that there is a significant correlation between Leptin hormone and total cholesterol (Chol) (r = 0.24), high density cholesterol (HDL) (r = 0.27) and low density cholesterol (LDL) (r = 0.16). There was no relationship between Leptin hormone and triglycerides (TG) (r = -0.02). There was relationship between Leptin hormone and waist circumference in both males and females (r = 0.519, 0.544), respectively. There was no statistical significant deference noticed between Leptin hormone of obese objects and Leptin hormone of normal BMI objects of the same age (t-test = 0.93, P = 0.85). Conclusion: There are significant correlations between Leptin hormone and total Chol, HDL and LDL except for TG, and there were significant relationships between Leptin hormone and waist circumference which reflect the central obesity among males and females. There is no association between Leptin level and BMI.

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Taleb, M. , Younis, S. , Zabout, B. , Najim, A. , Ahmed, A. and El-Bayary, E. (2014) Relationship of Serum Leptin, BMI, Waist Circumference and Cholesterol Level among Teenagers in the Gaza Strip. Pharmacology & Pharmacy, 5, 789-795. doi: 10.4236/pp.2014.58089.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Richard, S. and Strauss, M.D. (1999) Influence of the Home Environment on the Development of Obesity in Children. Pediatrics Journal, 103, 6.
[2] Jackson, R.T., Rashed, M. and Saad-Eldin, R. (2003) Rural Urban Differences in Weight, Body Image and Dieting Behavior among Adolescent Egyptian Schoolgirls. International Journal of Food Sciences and Nutrition, 54, 1-11.
[3] Miller, G.D., Nicklas, B.J., Davis, C.C., Ambrosius, W.T., Loeser, R.F. and Messier, S.P. (2004) Is Serum Leptin Related to Physical Function and Is It Modifiable through Weight Loss and Exercise in Older Adults with Knee Osteoarthritis? International Journal of Obesity, 28, 1383-1390.
[4] Wa, N. and Fogoros, M.D. (2011) Cholesterol and Trigleserids—What to You Need to Know, Health’s Disease and Condition Content Is Reviewed by the Medical Review Board.
[5] Hata, Y. and Nakajima, K. (2000) Life-Style and Serum Lipids and Lipoproteins. Journal of Atherosclerosis and Thrombosis, 7, 177-197.
[6] Schubert, C., Rogers, N., Remsberg, K., Sun, S., Chumelea, W., Demerath, E., Czerwinski, S., Towne, B. and Siervogel, R. (2006) Lipids, Lipoproteins, Lifestyle, Adiposity and Fat-Free Mass during Middle Age: The Fels Longitudinal Study. International Journal of Obesity, 6, 251-260.
[7] Cichocki, M. (2007) Cholesterol and Triglycerides a Balanced Diet Is a Key to Your Good Health, Health’s Disease and Condition Content Is Reviewed by the Medical Review Board.
[8] Figenschau, Y., Knutsen, G., Shahazeydi, S., Johansen, O. and Sveinbjornsson, B. (2001) Human Articular Chondrocytes Express Functional Leptin Receptors. The Journal of Clinical Endocrinology & Metabolism, 287, 190-197.
[9] Berman, D.M., Rodrigues, L.M., Nicklas, B.J., Ryan, A.S., Dennis, K.E. and Goldberg, A.P. (2001) Racial Disparities in Metabolism, Central Obesity, and Sex Hormone-Binding Globulin in Ostmenopausal Women. The Journal of Clinical Endocrinology & Metabolism, 86, 97-103.
[10] Harris, R.B., Zhou, J., Redmann Jr., S.M., Smagin, G.N., Smith, S.R., Rodgers, E. and Zachwieja, J.J. (1998) A Leptin Dose-Response Study in Obese (ob/ob) and Lean (+/?) Mice. Endocrinology, 139, 8-19.
[11] Verdich, C., Toubro, S., Buemann, B., Holst, J.J., Bulow, J., Simonsen, L., Sondergaard, S.B., Christensen, N.J. and Astrup, A. (2001) Leptin Levels Are Associated with Fat Oxidation and Dietary-Induced Weight Loss in Obesity. Obesity Research, 9, 452-461.
[12] Chu, N.F., Stampfer, M.J., Spiegelman, D., Rifai, N., Hotamisligil, G.S. and Rimm, E.B. (2001) Dietary and Lifestyle Factors in Relation to Plasma Leptin Concentrations among Normal Weight and Overweight Men. International Journal of Obesity, 25, 106-114.
[13] Frischr, R.E. (1994) The Right Weight: Body Fat, Menarche and Fertility. Proceedings of the Nutrition Society, 53, 113-129.
[14] Zabut, B., Naji, H., Holi, B. and Yousef, A. (2007) Leptin and Soluble Leptin Receptor among Obese Adults in the Gaza Strip. The Islamic University Journal (Series of Natural Studies and Engineering), 15, 127-140.
[15] Kasper, D., Fauci, A., Longo, D., Braunwald, E., Hauser, S.M.D. and Jameson, L. (2005) Harrison’s Principles of Internal Medicine. 16th Edition, MCGraw-Hill, New York, 399-422.
[16] Wu, D.-M., Shen, M.H. and Chu, N.F. (2001) Relationship between Plasma Leptin Levels and Lipid Profiles among School Children in Taiwan—The Taipei Children Heart Study. Europe Journal of Epidemiology, 17, 911-916.
[17] Haluzak, M., Fiedler, J., Nedvidkova, J. and Ceska, R. (2000) Serum Leptin Levels in Patients with Hyperlipidemias. Nutrition, 16, 429-433.
[18] MCKnight, T. (2006) Obesity Management in Family Practice. 1st Edition, Springer, Berlin, 38-41.
[19] Holmes, B. (1998) Childhood and Adolescent Obesity in America: What’s a Parent to do? University of Wyoming, USA.
[20] Palestinian Ministry of Health (MOH) (2008) Health Status in Palestine Annual Report.

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