Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1H-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate

Yang Liu, Guanghui Tian, Hongguang Ge, Xiaoyan Cao, Daihua Hu, Dehua Zhang

Department of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi, China.
School of Chemistry and Environmental Science, Shaanxi University of Technology, Hanzhong, China.

DOI: 10.4236/jcpt.2014.43018                

Abstract

An important anticancer nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5-(3-bromo-5-(methoxycar-bonyl)-1H-1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl diacetate was synthesized by directly coupling the bromotriazole with the protected ribose sugar, and have given the corresponding product in moderate yield. Its structure and conformation were confirmed by single crystal X-ray diffraction.

Keywords

Anticancer Nucleosides, Intermediate, Triazole Nucleosides

Conflicts of Interest

The authors declare no conflicts of interest.

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