Prospective Clinical Application of Thioredoxin Reductase as a Novel Diagnostic Tumor Marker
Suofu Ye, Nong Yang, Weiwei Ma, Yanran Fu, Lin Wu, Yueqin Li, Lihui Liu, Yi Hui, Yu Qiu, Siqing Mei, Yan Li, Huihui Zeng
1Health Science Center, Peking University, Beijing, China 2State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.
1Health Science Center, Peking University, Beijing, China 2State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China 4Keaise Clinical Examination Lab, Wuhan, China.
5Keaise Medicine (Tianjin) Co., Ltd, Tianjin, China 6Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin, China.
Department of Clinical Laboratory, Renmin Hospital, Wuhan University, Wuhan, China.
Department of Medical Oncology, Hunan Provincial Tumor Hospital, Changsha, China.
Keaise Clinical Examination Lab, Wuhan, China.
DOI: 10.4236/jbm.2014.24008   PDF   HTML     3,737 Downloads   4,970 Views   Citations


Background: Developing a novel, efficient biomarker for detecting malignant tumors is essential for the early diagnosis of cancers. Our aim was to assess the diagnostic value of a potential plasma tumor marker, thioredoxin reductase (TR), which is expressed in many types of malignant tumor, for the non-invasive detection of cancers. Methods: The plasma activities of TR were measured in 1513 patients with common clinical diseases, 59 patients with benign tumors, and 154 patients with cancers and 586 healthy controls. The area under the ROC curve (AUC) of TR and logistic regression results of different groups were compared by sensitivity, specificity and Youden’s index. Diagnostic cut-offs and clinical reference intervals were established via ROC curve analysis. Results: The logistic regression indicated that TR activity can discriminate between cancers and benign tumors or other common diseases very well (p < 0.0001), with an area under the curve from the receiver-operator characteristics between 0.91 and 0.96. The positive critical value was 2.51 and the cancer critical value was 9.90. The diagnostic gray zone (2.51 - 9.90) may be associated with benign tumors and some common clinical diseases. Conclusions: As a novel potential marker of malignant tumors with quantitative evaluation of proliferation, TR activity detection has an excellent diagnostic potential for early-stage malignant tumors. Impact: The convenient, economical, relatively non-invasive, and reproducible detection method of TR activity makes it suitable for routine clinical practice.

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Ye, S. , Yang, N. , Ma, W. , Fu, Y. , Wu, L. , Li, Y. , Liu, L. , Hui, Y. , Qiu, Y. , Mei, S. , Li, Y. and Zeng, H. (2014) Prospective Clinical Application of Thioredoxin Reductase as a Novel Diagnostic Tumor Marker. Journal of Biosciences and Medicines, 2, 44-53. doi: 10.4236/jbm.2014.24008.

Conflicts of Interest

The authors declare no conflicts of interest.


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