The Effects of a Hyaluronan Lotion with a Molecular Weight of around 50 - 110 kDa on the Aged Atrophic Skin

Asako Ito

doi:10.4236/jcdsa.2014.43021

Home > Journals > Medicine & Healthcare > JCDSA

Journal of Cosmetics, Dermatological Sci... > Vol.4 No.3, June 2014

The Effects of a Hyaluronan Lotion with a Molecular Weight of around 50 - 110 kDa on the Aged Atrophic Skin ()

Asako Ito

Ookuma Hospital, Nagoya, Japan.

DOI: 10.4236/jcdsa.2014.43021 PDF HTML 4,304 Downloads 6,307 Views Citations

Abstract

Background: Hyaluronic acids act upon keratinocytes via CD44 receptors and regulate proliferation and differentiation. Some cosmetic hyaluronan lotions manufactured based upon the fact are nowadays available. Aims: To evaluate a cosmetic hyaluronan lotion (Dr. Fukaya’s skin repair lotion or Hyaluprotect) from the viewpoint of anti-aging effects and to consider its mechanism. Patients/Methods: In ten healthy volunteers at the age over 60, immunohistochemical research of the biopsied skin was performed before and after the application of the hyaluronan lotion for two weeks. Results: Expression of PCNA in the lower epidermis increased in 8 of 10 subjects. Filaggrin expression of the upper epidermis increased in 6 subjects. 11βHSD1 decreased in 5 subjects and 11βHSD2 increased in 5 subjects. Conclusions: The proliferative and differentiative effects of the hyaluronan lotion upon keratinocytes were confirmed immunohistologically. There is a possibility that hyaluronic acids work through the regulation of corticosteroids by 11βHSD1 and 11βHSD2.

Keywords

Hyaluronic Acid, Anti-Aging, PCNA, Filaggrin, 11βHSD1, 11βHSD2, Atrophic Skin

Share and Cite:

Ito, A. (2014) The Effects of a Hyaluronan Lotion with a Molecular Weight of around 50 - 110 kDa on the Aged Atrophic Skin. Journal of Cosmetics, Dermatological Sciences and Applications, 4, 150-155. doi: 10.4236/jcdsa.2014.43021.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Kaya, G., Tran, C., Sorg, O., et al. (2006) Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism. PLoS Medicine, 3, 2291-2303. http://dx.doi.org/10.1371/journal.pmed.0030493
[2]	Barnes, L., Ino, F., Jaunin, F., Saurat, J.H. and Kaya, G. (2012) Inhibition of Putative Hyalurosome Platform in Keratinocytes as a Mechanism for Corticosteroid-Induced Epidermal Atrophy. Journal of Investigative Dermatology, 133, 1017-1026. http://dx.doi.org/10.1038/jid.2012.439
[3]	Bourguignon, L.Y., Wong, G., Xia, W., et al. (2013) Selective Matrix (Hyaluronan) Interaction with CD44 and RhoGTPase Signaling Promotes Keratinocyte Functions and Overcomes Age-Related Epidermal Dysfunction. Journal of Dermatological Science, 72, 32-44. http://dx.doi.org/10.1016/j.jdermsci.2013.05.003
[4]	Cirillo, N. and Prime, S.S. (2011) Keratinocytes Synthesize and Activate Cortisol. Journal of Cellular Biochemistry, 112, 1499-1505. http://dx.doi.org/10.1002/jcb.23081
[5]	Dahl, L.B., Kimpton, W.G., Cahill, R.N., Brown, T.J. and Fraser, R.E. (1989) The Origin and Fate of Hyaluronan in Amniotic Fluid. Journal of Developmental Physiology, 12, 209-218.
[6]	Ghazi, K., Deng-Pichon, U., Warnet, J.M. and Rat, P. (2012) Hyaluronan Fragments Improve Wound Healing on in Vitro Cutaneous Model through P2X7 Purinoreceptor Basal Activation: Role of Molecular Weight. PLoS One, 7, Article ID: e48351. http://dx.doi.org/10.1371/journal.pone.0048351
[7]	Pandey, M.S., Baggenstoss, B.A., Washburn, J., Harris, E.N. and Weigel, P.H. (2013) The Hyaluronan Receptor for Endocytosis (HARE) Activates NF-κB Mediated Gene Expression in Response to 40 - 400 kDa, but Not Smaller or Larger, Hyaluronan. Journal of Biological Chemistry, 288, 14068-14079. http://dx.doi.org/10.1074/jbc.M112.442889
[8]	Maytin, E.V., Chung, H.H. and Seetharaman, V.M. (2004) Hyaluronan Participates in the Epidermal Response to Disruption of the Permeability Barrier in Vivo. American Journal of Pathology, 165, 1331-1341. http://dx.doi.org/10.1016/S0002-9440(10)63391-3
[9]	Nyman, E., Huss, F., Nyman, T., Junker, J. and Kratz, G. (2013) Hyaluronic Acid, an Important Factor in the Wound Healing Properties of Amniotic Fluid: In Vitro Studies of Re-Epithelialisation in Human Skin Wounds. Journal of Plastic Surgery and Hand Surgery, 47, 89-92. http://dx.doi.org/10.3109/2000656X.2012.733169