Synthesis and Characterization of Some Selenium Nanometric Compounds: Spectroscopic, Biological and Antioxidant Assessments
Aly H. Atta, Ahmed I. El-Shenawy, Fathy A. Koura, Moamen S. Refat
Department of Chemistry, Faculty of Education, University of Dammam, Dammam, KSA; Department of Chemistry, Faculty of Science, Benha University, Benha, Egypt.
Department of Chemistry, Faculty of Education, University of Dammam, Dammam, KSA; Department of Chemistry, Faculty of Science, Suez University, Suez, Egypt.
Department of Chemistry, Faculty of Education, University of Dammam, Dammam, KSA;Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Department of Chemistry, Faculty of Science, Taif University, Al-Hawiah, KSA;Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt.
DOI: 10.4236/wjnse.2014.42009   PDF   HTML     4,693 Downloads   6,556 Views   Citations


Selenium (IV) vitamin A complex as antioxidant drug design was prepared and characterized by microanalysis, conductance, infrared spectra, Raman laser spectra, 1HNMR spectra, scanning electron microscopy (SEM), X-ray powder diffraction (XRD) and thermogravimetric (TG/DTG and DTA) tool of analyses. Vitamin A chelate was coordinated as a mono-dentate ligand through the oxygen atom of –OH hydroxyl group. Thermal degradation analyses discussed the removal of terminal methyl molecules in the first and second decomposition stage while the organic ligand moieties existed in the third and subsequence steps. The Se (IV) complex in comparable with free vitamin A ligand has been assessed against some kinds of bacteria and fungi which gave a significant inhibition. The surface morphology and nano scale size of selenium metal and its vitamin complex were proved. The activation energy and other thermodynamic parameters (ΔH*, ΔS* and ΔG*) of Se (IV) complex were calculated using Coats-Redfern and Horowitz-Metzger equations.

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Atta, A. , El-Shenawy, A. , Koura, F. and Refat, M. (2014) Synthesis and Characterization of Some Selenium Nanometric Compounds: Spectroscopic, Biological and Antioxidant Assessments. World Journal of Nano Science and Engineering, 4, 58-69. doi: 10.4236/wjnse.2014.42009.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Odom, J.D., Dawson, W.H. and Ellis, P.D. (1979) Selenium-77 Relaxation Time Studies on Compounds of Biological Importance: Dialkyl Selenides, Dialkyl Diselenides, Selenols, Selenonium Compounds, and Seleno Oxyacids. Journal of the American Chemical Society, 101, 5815-5822.
[2] Robberecht, H.J. and Deelstra, H.A. (1984) Selenium in Human Urine Determination, Speciation and Concentration Levels. Talanta, 31, 497-508.
[3] Andrews, R.W. and Johnson, D.C. (1975) Voltammetric Deposition and Stripping of Selenium(IV) at a Rotating Gold- Disk Electrode in 0.1M Perchloric Acid. Analytical Chemistry, 47, 294-299.
[4] Thomson, C.D. (2004) Assessment of Requirements for Selenium and Adequacy of Selenium Status: A Review. European Journal of Clinical Nutrition, 58, 391-402.
[5] Combs, G.F. and Gray, W.P. (1998) Chemopreventive Agents: Selenium. Pharmacology & Therapeutics, 79, 179-192.
[6] Levander, O.A. (1997) Nutrition and Newly Emerging Viral Diseases: An Overview. Journal of Nutrition, 127, 948S-950S.
[7] Corvilain, B., Contempre, B., Longombe, A.O., Goyens, P., Gervy-Decoster, C., Lamy, F., Vanderpas, J.B. and Dumont, J.E. (1993) Selenium and the Thyroid: How the Relationship Was Established. The American Journal of Clinical Nutrition, 57, 244S-248S.
[8] Sauberlich, H.E., Hodges, R.E., Wallace, D.L., Kolder, H., Canham, J.E., Hood, J., Raica Jr., N. and Lowry, L.K. (1974) A Metabolism and Requirements in the Human Studied with the Use of Labeled Retinol. Vitamins and Hormones: Advances on Research and Applications, 32, 251.
[9] Sommer, A. and West, K.P. (1996) Vitamin A Deficiency: Health, Survival, and Vision. Oxford University Press, New York, 100-116.
[10] Drevensek, P., Zupancic, T., Pihlar, B., Jerala, R., Kolitsch, U., Plaper, A. and Turel, I. (2005) Mixed-Valence Cu(II)/ Cu(I) Complex of Quinolone Ciprofloxacin Isolated by a Hydrothermal Reaction in the Presence of l-Histidine: Comparison of Biological Activities of Various Copper-Ciprofloxacin Compounds. Journal of Inorganic Biochemistry, 99, 432-442.
[11] He, J.H., Xiao, D.R., Chen, H.Y., Yan, S.W., Sun, D.Z., Wang, X., Yang, J., Yuan, R. and Wang, E.B. (2012) Two Novel Entangled Metal-Quinolone Complexes with Self-Threading and Polythreaded Characters. Inorganica Chimica Acta, 385, 170-177.
[12] Kathawate, L., Sproules, S., Pawar, O., Markad, G., Haram, S., Puranik, V. and Salunke-Gawali, S. (2013) Synthesis and Molecular Structure of a Zinc Complex of the Vitamin K3 Analogue Phthiocol. Journal of Molecular Structure, 1048, 223-229.
[13] Gielen, M. and Tiekink, E.R.T. (2005) Metallotherapeutic Drugs and Metal-Based Diagnostic Agents, the Use of Metals in Medicine. Wiley, Chichester.
[14] Weder, J.E., Dillon, C.T., Hambley, T.W., Kennedy, B.J., Lay, P.A., Biffin, J.R., Regtop, H.L. and Daview, N.M. (2002) Copper Complexes of Non-Steroidal Anti-Inflammatory Drugs: An Opportunity Yet to Be Realized. Coordination Chemistry Reviews, 232, 95-126.
[15] Ware, D.C., Brothers, P.J. and Clark, G.R. (2000) Synthesis, Structures and Hypoxia-Selective Cytotoxicity of Cobalt(III) Complexes Containing Tridentate Amine and Nitrogen Mustard Ligands. Journal of the Chemical Society, Dalton Transactions, 6, 925-932.
[16] Nakai, M., Sekiguchi, F., Obata, M., Ohtsuki, C., Adachi, Y., Sakurai, H., Orvig, C., Rehder, D. and Yano, S. (2005) Synthesis and Insulin-Mimetic Activities of Metal Complexes with 3-Hydroxypyridine-2-Carboxylic Acid. Journal of Inorganic Biochemistry, 99, 1275-1282.
[17] Muller, J.G. and Burrows, C.J. (1998) Metallodrug Complexes That Mediate DNA and Lipid Damage via Sulfite Autoxidation: Copper(II) Famotidine and Iron(III) Bis(Salicyglycine). Inorganica Chimica Acta, 275-276, 314-319.
[18] Duda, A.M., Kowalik-Jankowska, T., Kozlowski, H. and Kupka, T. (1995) Histamine H2 Antagonists: Powerful Ligands for Copper(II). Reinterpretation of the Famotidine-Copper(II) System. Journal of the Chemical Society, Dalton Transactions, No. 17, 2909-2913.
[19] Kubiak, M., Duda, A.M., Ganadu, M.L. and Kozlowski, H. (1996) Crystal Structure of a Copper(II)-Famotidine Complex and Solution Studies of the Cu2+-Famotidine-Histidine Ternary System. Journal of the Chemical Society, Dalton Transactions, No. 9, 1905-1908.
[20] Wu, C.-D., Lu, C.-Z., Zhuang, H.-H. and Huang, J.-S. (2002) Hydrothermal Assembly of a Novel Three-Dimensional Framework Formed by [GdMo12O42]9- Anions and Nine Coordinated GdIII Cations. Journal of the American Chemical Society, 124, 3836-3837.
[21] Dybtsev, D.N., Chun, H. and Kim, K. (2004) Rigid and Flexible: A Highly Porous Metal-Organic Framework with Unusual Guest-Dependent Dynamic Behavior. Angewandte Chemie International Edition, 43, 5033-5036.
[22] López-Gresa, M.P., Ortiz, R., Perelló, L., Latorre, J., Liu-González, M., Garcia-Grand, S., Pérez-Priede, M. and Cantón, E. (2002) Interactions of Metal Ions with Two Quinolone Antimicrobial Agents (Cinoxacin and Ciprofloxacin): Spectroscopic and X-Ray Structural Characterization. Antibacterial Studies. Journal of Inorganic Biochemistry, 92, 65-74.
[23] Xiao, D.-R., Wang, E.-B., An, H.-Y., Li, Y.-G. and Xu, L. (2007) Syntheses and Structures of Three Unprecedented Metal-Ciprofloxacin Complexes with Helical Character. Crystal Growth & Design, 7, 506-512.
[24] Xiao, D.R., He, J.H., Sun, D.Z., Chen, H.Y., Yan, S.W., Wang, X., Yang, J., Yuan, R. and Wang, E.B. (2012) Three 3D Metal-Quinolone Complexes Based on Trimetallic or Rod-Shaped Secondary Building Units. European Journal of Inorganic Chemistry, 2012, 1783-1789.
[25] Refat, M.S. and El-Sabawy, K.M. (2011) Infrared Spectra, Raman Laser, XRD, DSC/TGA and SEM Investigations on the Preparations of Selenium Metal, (Sb2O3, Ga2O3, SnO and HgO) Oxides and Lead Carbonate with Pure Grade Using Acetamide Precursors. Bulletin of Materials Science, 34, 873-881.
[26] Gupta, R., Saxena, R.K., Chatarvedi, P. and Virdi, J.S. (1995) Chitinase Production by Streptomyces viridificans: Its Potential in Fungal Cell Wall Lysis. Journal of Applied Bacteriology, 78, 378-383.
[27] Scherrer, P. (1918) Bestimmung der Grobe und der inneren Struktur von Kolloidteilchen mittels Rontgenstrahlen. Nachrichten von der Gesellschaft der Wissenschaften zu Gottingen, 2, 98-100.
[28] Iovu, M.S., Kamitsos, E.I., Varsamis, C.P.E., Boolchand, P. and Popescu, M. (2005) Raman Spectra of AsxSe100-x and As40Se60 Glassesdoped with Metals. Chalcogenide Letters, 2, 21-25.
[29] Kovanda, V., Vlcek, M. and Jain, H. (2003) Structure of As-Se and As-P-Se Glasses Studied by Raman Spectroscopy. Journal of Non-Crystalline Solids, 326-327, 88-92.
[30] Refat, M.S. (2007) Complexes of Uranyl(II), Vanadyl(II) and Zirconyl(II) with Orotic Acid “Vitamin B13”: Synthesis, Spectroscopic, Thermal Studies and Antibacterial Activity. Journal of Molecular Structure, 842, 24-37.
[31] Vogel, T. (1989) Vogel Textbook of Practical Organic Chemistry. 4th Edition, Wiley & Sons, Inc., New York, 133- 325.
[32] Nakamoto, K. (1970) Infrared Spectra of Inorganic and Coordination Compounds. Wiley InterScience, New York.
[33] Mohamed, G.G., Zayed, M.A., Nour El-Dien, F.A. and El-Nahas, R.G. (2004) IR, UV-Vis, Magnetic and Thermal Characterization of Chelates of Some Catecholamines and 4-Aminoantipyrine with Fe(III) and Cu(II). Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 60, 1775-1781.
[34] Santi, E., Torre, M.H., Kremer, E., Etcheverry, S.B. and Baran, E. (1993) Vibrational Spectra of the Copper(II) and Nickel(II) Complexes of Piroxicam. Vibrational Spectroscopy, 5, 285-293.
[35] Arumuganathan, T., Srinivasarao, A., Kumar, T.V. and Das, S.K. (2008) Two Different Zinc(II)-Aqua Complexes Held Up by a Metal-Oxide Based Support: Synthesis, Crystal Structure and Catalytic Activity of [HMTAH]2[{Zn(H2O)5}{Zn(H2O)4}{Mo7O24}]2H2O (HMTAH = Protonated Hexamethylenetetramine). Journal of Chemical Sciences, 120, 95-103.
[36] Freeman, E.S. and Carroll, B. (1958) The Application of Thermoanalytical Techniques to Reaction Kinetics: The Thermogravimetric Evaluation of the Kinetics of the Decomposition of Calcium Oxalate Monohydrate. The Journal of Physical Chemistry, 62, 394-397.
[37] Coats, A.W. and Redfern, J.P. (1964) Kinetic Parameters from Thermogravimetric Data. Nature, 201, 68-69.
[38] Horowitz, H.W. and Metzger, G. (1963) A New Analysis of Thermogravimetric Traces. Analytical Chemistry, 35, 1464-1468. v
[39] Flynn, J.H.F. and Wall, L.A. (1966) General Treatment of the Thermogravimetry of Polymers. Journal of Research of the National Bureau of Standards, 70A, 487-523.
[40] Peng, D.G., Zhang, J.S., Liu, Q.L. and Taylor, E.W. (2007) Size Effect of Elemental Selenium Nanoparticles (Nano-Se) at Supranutritional Levels on Selenium Accumulation and Glutathione S-Transferase Activity. Journal of Inorganic Biochemistry, 101, 1457-1463.
[41] Jam, P. and Chaturvedi, K.K. (1976) Potentiometric Study of the Complexes of Sulphamethazine Salicylaldimine with Cu(II), Ni(II) and Co(II). Journal of Inorganic and Nuclear Chemistry, 38, 799-800.
[42] Jam, P. and Chaturvedi, K.K. (1977) Complexes of Cu(II), Ni(II) and Co(II) with Sulphamerazine. Journal of Inorganic and Nuclear Chemistry, 39, 901-903.

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