Accelerated Atherosclerosis in a Young Female with Familial Hypercholesterolemia

Adikesava Naidu Otikunta, Praneeth Polamuri, Subba Reddy Y V, Ravi Srinivas, Ashok Thakkar, Arohi Sarang

Department of Cardiology, Osmania General Hospital & Osmania Medical College, Hyderabad, India.
Department of Clinical Trials, Sahajanand Medical Technologies Pvt. Ltd., Surat, India.

DOI: 10.4236/ijcm.2014.510074                

Abstract

Familial hypercholesterolemia is an autosomal dominant genetic disease due to mutation in low-density lipoprotein-cholesterol receptor gene. It is characterized by elevated plasma low-density lipoprotein-cholesterol and the consequence of which leads to premature cardiovascular disease. The mainstay in the management of familial hypercholesterolemia patient is the treatment with high potency statin. However, current research shows influence of the type of low-density lipoprotein-cholesterol receptor mutations on severity of the cardiovascular disease, lipid profile, and response to statin treatment. We are here presenting a case of young Indian female patient who was diagnosed with familial hypercholesterolemia and treated with percutaneous transluminal coronary angioplasty in view of double vessel disease in the third decade of her life. She was prescribed with statin therapy for elevated low-density lipoprotein cholesterol. After 3 years, she presented once again with a triple vessel disease along with patent stented segments and abnormal lipid profile.

Keywords

Familial Hypercholesterolemia, Premature Coronary Artery Disease, Statin

Conflicts of Interest

The authors declare no conflicts of interest.

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