The Amen Anti-Addiction Intervention: Theoretical Foundations of a Novel Neurotrophic Protocol for the Prevention and Treatment of Addiction


The Amen Anti-Addiction Intervention (AAI) is an austere regimen intended to eradicate addictive impulses and behaviors. The theoretical and empirical foundations of this intervention are explicated herein. The AAI entails daily cyclic fasting, chronic caloric restriction, supplementation with specific neutraceutical agents, rigorous exercise, and minimalist meditation. The physiological focus of the AAI is twofold: the augmentation of neurogenesis in a manner analogous to the effect of psychotropic drugs and the activation of areas in the brain involved in the regulation of emotional arousal and reward. The psychological focus of the AAI is similarly twofold: the attenuation of anxiety and/or impulsivity and the cultivation of mental mastery and/or self-control. It shall be argued that the AAI, by virtue of its explicit integration of biological, psychological, and sociological elements—each of which evidently influences addiction—will plausibly be an improvement over existing interventions aimed at the treatment of addiction.

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Amen-Ra, N. (2014) The Amen Anti-Addiction Intervention: Theoretical Foundations of a Novel Neurotrophic Protocol for the Prevention and Treatment of Addiction. Neuroscience and Medicine, 5, 79-85. doi: 10.4236/nm.2014.52011.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Abadinsky, H. (2010) Drug Use & Abuse: A Comprehensive Introduction. 7th Edition, Cenage Learning, Belmont.
[2] Amen-Ra, N. (2013) The Amen Optimal Health Protocol: An Exposition on the Experimental, Theoretical & Practical Underpinnings of Lifespan Extension & Optimal Health Promotion, a Discourse on the Method of Gerostasis, Volumes I-III. Amenta Press, Damascus.
[3] Amen-Ra, N. (2007) The Optimal Human Diet: Theoretical Foundations of the Amen Protocol. In: Robitaille, F.P., Ed., Diet Therapy Research Trends, Nova Science, New York, 177-240.
[4] Pechnick, R.N., Zonis, S., Wawrowsky, K., Cosgayon, R., et al. (2011) Antidepressants Stimulate Hippocampal Neurogenesis by Inhibiting p21 Expression in the Subgranular Zone of the Hippocampus. PLoS One, 6, e27290.
[5] Duan, W., Guo, Z. and Mattson, M.P. (2001) Brain-Derived Neurotrophic Factor Mediates an Excitoprotective Effect of Dietary Restriction in Mice. Journal of Neurochemistry, 76, 619-626.
[6] Herrera, D.G., Yague, A.G., Johnsen-Soriano, S., et al. (2003) Selective Impairment of Hippocampal Neurogenesis by Chronic Alcoholism: Protective Effects of an Antioxidant. Proceedings of the National Academy of Sciences of the United States of America, 100, 7919-7924.
[7] Eisch, A.J. and Harburg, G.C. (2006) Opiates, Psychostimulants, and Adult Hippocampal Neurogenesis: Insights for Addiction and Stem Cell Biology. Hippocampus, 16, 271-286.
[8] Sudai, E., Croitoru, O., Shaldubina, A., et al. (2011) High Cocaine Dosage Decreases Neurogenesis in the Hippocampus and Impairs Working Memory. Addiction Biology, 16, 251-260.
[9] Teuchert-Noodt, G., Dawirs, R.R. and Hildebrandt, K. (2000) Adult Treatment with Methamphetamine Transiently Decreases Dentate Granule Cell Proliferation in the Gerbil Hippocampus. Journal of Neural Transmission, 107, 133-143.
[10] Huang, G.J., Ben-David, E., Tort Piella, A., et al. (2012) Neurogenomic Evidence for a Shared Mechanism of the Antidepressant Effects of Exercise and Chronic Fluoxitine in Mice. PLoS One, 7, e35901.
[11] Curlik, D.M. and Shors, T.J. (2013) Training Your Brain: Do Mental and Physical (MAP) Training Enhance Cognition through the Process of Neurogenesis in the Hippocampus? Neuropharmacology, 64, 506-514.
[12] Esch, T., Stefano, G.B., Fricchione, G.L. and Benson, H. (2002) The Role of Stress in Neurodegenerative Diseases and Mental Disorders. Neuroendocrinology Letters, 23, 199-208.
[13] Marchand, W.R. (2013) Mindfulness Meditation Practices as Adjunctive Treatments for Psychiatric Disorders. Psychiatric Clinics of North America, 36, 141-152.
[14] Witkiewitz, K., Lustyk, M.K. and Bowen, S. (2013) Retraining the Addicted Brain: A Review of Hypothesized Neurobiological Mechanisms of Mindfulness-Based Relapse Prevention. Psychology of Addictive Behaviors, 27, 351-365.
[15] Brewer, J.A., Sinha, R., Chen, J.A., et al. (2009) Mindfulness Training and Stress Reactivity in Substance Abuse: Results from a Randomized, Controlled Stage I Pilot Study. Substance Abuse, 30, 306-317.
[16] Holzel, B.K., Carmody, J., Vangel, M., et al. (2011) Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density. Psychiatry Research: Neuroimaging, 191, 36-43.
[17] Glenn, M.J., Adams, R.S. and McClurg, L. (2012) Supplemental Dietary Choline during Development Exerts Antidepressant-Like Effects in Adult Female Rats. Brain Research, 1443, 52-63.
[18] Jiang, B., Xiong, Z., Yang, J., et al. (2012) Antidepressant-Like Effects of Ginsenoside Rg1 Are Due to Activation of the BDNF Signalling Pathway and Neurogenesis in the Hippocampus. British Journal of Pharmacology, 166, 1872-1887.
[19] Costa, M.S., Botton, P.H., Mioranzza, S., et al. (2008) Caffeine Improves Adult Mice Performance in the Object Recognition Task and Increases BDNF and TrkB Independent on phospho-CREB Immunocontent in the Hippocampus. Neurochemistry International, 53, 89-94.
[20] Casadesus, G., Shukitt-Hale, B., Stellwagen, H.M., et al. (2004) Modulation of Hippocampal Plasticity and Cognitive Behavior by Short-Term Blueberry Supplementation in Aged Rats. Nutritional Neuroscience, 7, 309-316.
[21] Fernández-Fernández, L., Comes, G., Bolea, I., et al. (2012) LMN Diet, Rich in Polyphenols and Polyunstaturated Fatty Acids, Improves Mouse Cognitive Decline Associated with Aging and Alzheimer’s Disease. Behavioural Brain Research, 228, 261-271.
[22] Yoo, D.Y., Kim, W., Yoo, K.Y., et al. (2011) Grape Seed Extract Enhances Neurogenesis in the Hippocampal Dentate Gyrus in C57BL/6 Mice. Phytotherapy Research, 25, 668-674.
[23] Bachstetter, A.D., Jernberg, J., Schlunk, A., et al. (2010) Spirulina Promotes Stem Cell Genesis and Protects Against LPS Induced Declines in Neural Stem Cell Proliferation. PLoS ONE, 5, e10496.
[24] Nam, S.M., Yoo, D.Y., Kim, W., et al. (2011) Effects of S-Allyl-L-Cysteine on Cell Proliferation and Neuroblast Differentiation in the Mouse Dentate Gyrus. Journal of Veterinary Medical Science, 73, 1071-1075.
[25] Pan, M., Li, Z., Yeung, V. and Xu, R.J. (2010) Dietary Supplementation of Soy Germ Phytoestrogens or Estradiol Improves Spatial Memory Performance and Increases Gene Expression of BDNF, TrkB Receptor and Synaptic Factors in Ovariectomized Rats. Nutrition & Metabolism (Lond), 7, 75.
[26] Wang, Y., Li, M., Xu, X., et al. (2012) Green Tea Epigallocatechin-3-Gallate (EGCG) Promotes Neural Progenitor Cell Proliferation and Sonic Hedgehog Pathway Activation during Adult Hippocampal Neurogenesis. Molecular Nutrition & Food Research, 56, 1292-1303. Http://Dx.Doi.Org/10.1002/Mnfr.201200035
[27] Dias, G., Cavegn, N., Nix, A., et al. (2012) The Role of Dietary Polyphenols on Adult Hippocampal Neurogenesis: Molecular Mechanisms and Behavioural Effects on Depression and Anxiety. Oxidative Medicine and Cellular Longevity, 2012, Article ID: 541971.
[28] Kim, I.Y., Hwang, I.K., Choi, J.W., et al. (2009) Effects of High Cholesterol Diet on Newly Generated Cells in the Dentate Gyrus of C57BL/6N and C3H/HeN Mice. Journal of Veterinary Medical Science, 71, 753-758.
[29] Can, Ö.D., Ulupinar, E., Özkay, Ü.D., Yegin, B. and Öztürk, Y. (2012) The Effect of Simvastatin Treatment on Behavioral Parameters, Cognitive Performance, and Hippocampal Morphology in Rats Fed a Standard or a High-Fat Diet. Behavioural Pharmacology, 23, 582-592.
[30] Inanami, O., Asanuma, T., Inukai, N., et al. (1995) The Suppression of Age-Related Accumulation of Lipid Peroxides in Rat brain by Administration of Rooibos Tea (Aspalathus linearis). Neuroscience Letters, 196, 85-88.
[31] Vetulani, J. (2001) Drug Addiction. Part II. Neurobiology of Addiction. Polish Journal of Pharmacology, 53, 303-317.
[32] Blum, K., Liu, Y., Shriner, R. and Gold, M.S. (2011) Reward Circuitry Dopaminergic Activation Regulates Food and Drug Craving Behavior. Current Pharmaceutical Design, 17, 1158-1167.
[33] McCarthy, D.M., Brown, A.N. and Bhide, P.G. (2012) Regulation of BDNF Expression by Cocaine. Yale Journal of Biology and Medicine, 85, 437-446.
[34] Gardner, E.L. (2011) Addiction and Brain Reward and Anti-Reward Pathways. Advances in Psychosomatic Medicine, 30, 22-60.
[35] Orford, J. (2001) Addiction as Excessive Appetite. Addiction, 96, 15-31.
[36] Sussman, S. and Sussman, A.N. (2001) Considering the Definition of Addiction. International Journal of Environmental Research and Public Health, 8, 4025-4038.
[37] Yamamoto, Y., Tanahashi, T., Kawai, T., et al. (2009) Changes in Behavior and Gene Expression Induced by Caloric Restriction in C57BL/6 Mice. Physiological Genomics, 39, 227-235.
[38] Fang, J., Gu, J.W., Yang, W.T., Qin, X.Y. and Hu, Y.H. (2012) Clinical Observation of Physiological and Psychological Reactions to Electric Stimulation of the Amygdaloid Nucleus and the Nucleus Accumbens in Heroin Addicts after Detoxification. Chinese Medical Journal (English Edition), 125, 63-66.
[39] Carr, K.D. (2002) Augmentation of Drug Reward by Chronic Food Restriction: Behavioral Evidence and Underlying Mechanisms. Physiology & Behavior, 76, 353-364.
[40] Ozburn, A.R., Harris, R.A. and Blednov, Y.A. (2008) Wheel Running, Voluntary Ethanol Consumption, and Hedonic Substitution. Alcohol, 42, 417-424.
[41] Varady, K.A. (2011) Intermittent Versus Daily Calorie Restriction: Which Diet Regimen Is More Effective for Weight Loss? Obesity Reviews, 12, e593-e601.
[42] Rothwell, P.E., Thomas, M.J. and Gewirtz, J.C. (2009) Distinct Profiles of Anxiety and Dysphoria during Spontaneous Withdrawal from Acute Morphine Exposure. Neuropsychopharmacology, 34, 2285-2295.
[43] Chen, K.W., Berger, C.C., Manheimer, E., et al. (2012) Meditative Therapies for Reducing Anxiety: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Depression and Anxiety, 29, 545-562.
[44] Amen-Ra, N. (2011) Mind, Matter, Mathematics, & Mortality: Meditations on a Momentous Metaphysical Theory. Amenta Press, Damascus.
[45] Bowen, S., Chawla, N., Collins, S.E., et al. (2009) Mindfulness-Based Relapse Prevention for Substance Use Disorders: A Pilot Efficacy Trial. Substance Abuse, 30, 295-305.
[46] Jacobi, H. (1895) Jaina Sutras (Part II). In: Muller, F.M., Ed., The Sacred Books of the East, Oxford University Press, Oxford, 55.

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