Hereditary Immunity and the Origin of Atherosclerosis

Sergey N. Rumyantsev, Vil K. Gerasimov, Jergy Grzezczuk, Roman A. Aron, Nataly F. Avrova, Irina V. Belyakova, Ludmila V. Bobrakova, Kirill F. Dubrov, Ludmila V. Perkus, Vladimir F. Pospelov, Nina M. Rogacheva, Nikolay P. Shabalov

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Department of Evolutionary Immunology, Andent, Inc., Jersey City, USA.

DOI: 10.4236/oji.2014.41003                

Abstract

This paper tries to present new confirmation for the opinion about the infectious origin of atherosclerosis from the viewpoint of the current knowledge of hereditary immunity. The performed integrative investigation included the reinterpretation of known clinical and epidemiological observations, supported by immunological, molecular ecological, genetic, and genomic discoveries. The revealed body of firstly achieved information is compatible with the concept that infectious agents contribute the clue step to the development of atherosclerosis over its initial stage performed during the triggering of the arterial endothelial wall by the molecular agent of proposed infectious origin.

Keywords

Epidemic Spread; Heterozygosity; Homozygosity; Immune Mosaicism; Integrative Approach; Plaque Formation

Conflicts of Interest

The authors declare no conflicts of interest.

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