Share This Article:

Evaluation of Skin Elasticising Topical Formulations by a Torsiometric Test

Abstract Full-Text HTML Download Download as PDF (Size:339KB) PP. 73-77
DOI: 10.4236/jcdsa.2014.42011    3,425 Downloads   4,589 Views   Citations

ABSTRACT

Background/Purpose: In the frame of a development of a formulation to be used in perineal massage in pregnant women, a screening program was built up among compositions with elasticising properties. Methods: This was an open-label, controlled study in 21 volunteers. The participants applied once, on the volar surface of both forearms, five formulations with elasticising properties (test products 1 to 5) and a reference standard (test product 6). The formulations were applied on three sites on each forearm that were randomly assigned. Skin elasticising parameters were evaluated using the Dermal Torque Meter, at baseline and 30 minutes after application. Results: Among the test products, only test product 2 significantly increased skin elasticity compared with the baseline value, with a trend toward superiority versus the reference standard (+24% vs. +13%, respectively). There was a significant increase in elastic recovery of 23% with test product 2, compared with a significant increase of 13% with the reference standard. Conclusion: Test product 2, comprising a thiolated compound and a mixture of esters of fatty acids, had the greatest elasticising effect. Compared with the other tested formulations, product 2 led to a greater increase in extensibility and faster elastic recovery of the skin on the volar surface of the forearm.

Cite this paper

Sparavigna, A. , Scarci, F. and Mailland, F. (2014) Evaluation of Skin Elasticising Topical Formulations by a Torsiometric Test. Journal of Cosmetics, Dermatological Sciences and Applications, 4, 73-77. doi: 10.4236/jcdsa.2014.42011.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Morrison, D.S. (1996) Petrolatum: A Useful Classic. Cosmetics and Toiletries Magazine, 111, 59-69.
[2] Uchimoto, T., et al. (2010) Lubrication Properties of Potential Alternative Lubricants, Glycerin Fatty Acid Esters, to Magnesium Stearate. International Journal of Pharmaceutics, 386, 91-98. http://dx.doi.org/10.1016/j.ijpharm.2009.11.001
[3] Acimovic, J.M., Stanimirovic, B.D. and Mandic, L.M. (2009) The Role of the Thiol Group in Protein Modification with Methylglyoxal. Journal of the Serbian Chemical Society, 74, 867-883.
http://dx.doi.org/10.2298/JSC0909867A
[4] Proksch, E. and Lachapelle, J.M. (2005) The Management of Dry Skin with Topical Emollients-Recent Perspectives. Journal der Deutschen Dermatologischen Gesellschaft, 3, 768-774.
http://dx.doi.org/10.1111/j.1610-0387.2005.05068.x
[5] Reggiardo, G., Fasani, R. and Mignini, F. (2012) Multicentre, Open Label Study to Evaluate the Efficacy and Tolerability of a Gel (Elastolabo?) for the Reduction of the Incidence of Perineal Traumas during Labour and Related Complications in the Postpartum Period. Trends in Medicine, 12, 143-149.

  
comments powered by Disqus

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.