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Synthesis and antimicrobial activity of Ibuprofen derivatives

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DOI: 10.4236/ns.2014.62008    5,784 Downloads   8,475 Views   Citations

ABSTRACT

In order to reduce the ulcerogenic effect of ibuprofen, its carboxylic group has been converted into 5-membered and 6-membered heterocyclic rings. Various 1,3,4-thiadaizo (y), imidazo [2,1-b] [1,3,4] thiadiazoles (1a-d), 1,3-oxazin-2-yl (2), quinazolin-2-yl (3, 4 and 5), hydrazine, pyrazole (6), pyrazone (7, 8) and oxadiazole (9, 12). Derivatives of ibuprofen were prepared by cyclization under various reaction conditions in a very good yield. The microbial inhibitory effect of the new agents has been assessed in vitro against Gram-positive and Gram-negative bacteria activity. Compounds (4, 5, and 8) showed the highest antibacterial activities compared to other compounds and standard drugs. However, compound (1b) showed the lowest antibacterial activity compared to other compounds. All compounds have been characterized by IR, 1H NMR and C.H.N analysis.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Abdulla, I. (2014) Synthesis and antimicrobial activity of Ibuprofen derivatives. Natural Science, 6, 47-53. doi: 10.4236/ns.2014.62008.

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