Multicenter Analysis of mFOLFOX6 with Oxaliplatin Stop-and-Go Strategy Using Oral Uracil-Tegafur with Leucovorin for Unresectable Colorectal Cancer in Elderly Patients
Tetsu Yamamoto, Kuniyuki Katano, Shinichi Sugimoto, Akiyoshi Kanazawa, Eiji Hira, Hiroshi Takeda, Yoshitoshi Sato, Yutaka Yamashiro, Yoshitsugu Tajima, Masahide Ikeguchi
Department of Digestive and General Surgery, Faculty of Medicine, Shimane University, Izumo, Japan.
Department of Gastroenterological Surgery, Matsue Red Cross Hospital, Matsue, Japan.
Department of Gastroenterological Surgery, Osaka Red Cross Hospital, Osaka, Japan.
Department of Gastroenterological Surgery, Tottori Red Cross Hospital, Tottori, Japan.
Department of Surgery, Saihaku Hospital, Saihaku, Japan.
Department of Surgery, Shimane Prefectural Central Hospital, Izumo, Japan.
Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago, Japan.
DOI: 10.4236/jct.2014.52018   PDF    HTML     4,182 Downloads   6,228 Views   Citations


Background: This study evaluated the tolerability and efficacy of intermittent oxaliplatin treatment based on mFOLFOX6 using oral uracil-tegafur(UFT) and leucovorin(LV) maintenance therapy in the treatment of elderly patients with advanced colorectal cancer. Methods: Ten non-elderly patients (<70 years) and 8 elderly patients (>70 years) with advanced/recurrent colorectal cancer were enrolled in this prospective, multicenter cooperative group clinical trial. The mFOLFOX6 regimen was administered for eight cycles with maintenance therapy with oral UFT/LV treatment until progression. In cases with disease progression, mFOLFOX6 was reintroduced. Results: Grade 2 peripheral neuropathy was noted in 30.0% and 25.0% of the elderly and non-elderly patients, respectively. The observed time to treatment failure (TTF) was 6.3 months in the elderly patients and 6.4 months in the non-elderly patients. The disease control rate was 83.3% in each group. Conclusion: Our new stop-and-go strategy using oral UFT/LV is well-tolerated and effective even in elderly patients.

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T. Yamamoto, K. Katano, S. Sugimoto, A. Kanazawa, E. Hira, H. Takeda, Y. Sato, Y. Yamashiro, Y. Tajima and M. Ikeguchi, "Multicenter Analysis of mFOLFOX6 with Oxaliplatin Stop-and-Go Strategy Using Oral Uracil-Tegafur with Leucovorin for Unresectable Colorectal Cancer in Elderly Patients," Journal of Cancer Therapy, Vol. 5 No. 2, 2014, pp. 147-154. doi: 10.4236/jct.2014.52018.

Conflicts of Interest

The authors declare no conflicts of interest.


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