S100B and delirium in the geriatric acute care setting

Walaa W. Aly, Samia A. Abdul-Rahman, Salma M. S. El Said, Samah A. Bastawy

Department of Clinical Pathology, Cardiothoracic Surgical Center, Ain Shams University Hospitals, Cairo, Egypt.
Department of Geriatrics and Gerontology, Ain Shams University, Cairo, Egypt.
Department of Geriatrics and Gerontology, Ain Shams University, Cairo, Egypt;.

DOI: 10.4236/aar.2014.31001                

Abstract

Delirium and its relation to biochemical markers have been considered a study question in several research works. The relation between S100B levels and delirium is still a matter of discussion. Objective: To compare the serum level of S100B in patients with and without delirium and to detect the relation between S100B and delirium subtypes. Method: A case control study was conducted on 114 elderly (60 years and older) selected from the geriatric acute care unit at Ain Shams University Hospitals. They were classified into two groups; 58 elderly cases who had delirium diagnosed by Confusion Assessment Method and 56 controls. Then delirium was reclassified according to the subtypes of delirium into Hyperactive: 46 patients, hypoactive: 2 patients, and Mixed: 10 patients. Serum S100B levels were determined by ELISA. Results: Cases were significantly older than controls (72.4 ± 9.4 versus 66.9 ± 5.3 years respectively) (P < 0.001). S100B levels were higher in cases (32.4 ± 9.8 pg/ml) than controls (30 ± 9.3 pg/ml) but the difference was not statistically significant (P = 0.19). There was no significant difference in S100B levels between the different subtypes of delirium. Conclusion: Delirious patients had higher S100B levels than controls but the difference was not statistically significant.

Keywords

Delirium; S100B; Elderly

Conflicts of Interest

The authors declare no conflicts of interest.

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