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Purine nucleotides and their metabolites in patients with type 1 and 2 diabetes mellitus

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DOI: 10.4236/jbise.2014.71006    2,930 Downloads   5,024 Views   Citations

ABSTRACT

We measured the erythrocyte levels of principal nucleotides (ATP, ADP, AMP, GTP, GDP, GMP, IMP), nucleosides (Ado, Guo, Ino) and Hyp with HPLC. Purine concentrations were determined in the erythrocytes of 36 type 1 and 40 type 2 diabetic patients. The increased dephosphorylation of adenine and guanine nucleotides, indicated by increased Ado, Ino, Guo and Hyp concentrations as the products of purine nucleotide degradation, suggests serious energy metabolism disruptions in diabetes. An increase in AMP, GMP, IMP concentrations, as well as a decrease in AEC and GEC values, points to significant alterations in erythrocyte purine nucleotide concentration.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Dudzinska, W. (2014) Purine nucleotides and their metabolites in patients with type 1 and 2 diabetes mellitus. Journal of Biomedical Science and Engineering, 7, 38-44. doi: 10.4236/jbise.2014.71006.

References

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