Meta-analyses of nine polymorphisms of six genes with the risk of schizophrenia


The aim of this study was to determine whether 9 genetic polymorphisms confered susceptibility to schizophrenia (SCZ). The authors conducted meta-analyses on associations between SCZ and 9 variants of 6 genes including PIK3C3 (432C > T), ABCB1 (C3435T and G2677T), CTLA4 (+49A/G), OLIG2 (rs762178), GAD1 (rs1978340, rs3749034 and rs769395), and GRIN1 (G1001C). A total of 34 case-control studies were involved in our meta-analyses. Our results showed no significant association between all the loci and SCZ. This meta-analysis confirmed a lack of association of SCZ for 9 genetic polymorphisms including GRIN1 G1001C, ABCB1 C3435T and G2677T, CTLA4 + 49A/G, OLIG2 rs762178, GAD1 gene rs1978340, rs3749034 and rs769395, and PIK3C3 432C > T.

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Xu, X. , Wang, L. , Liao, Q. , Xu, L. , Huang, Y. , Zhang, F. , Cheng, J. , Ye, M. , Gao, S. and Duan, S. (2014) Meta-analyses of nine polymorphisms of six genes with the risk of schizophrenia. Advances in Bioscience and Biotechnology, 5, 81-88. doi: 10.4236/abb.2014.52012.

Conflicts of Interest

The authors declare no conflicts of interest.


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