Skin Hydrating Effects of Corchorus olitorius Extract in a Mouse Model of Atopic Dermatitis

DOI: 10.4236/jcdsa.2014.41001   PDF   HTML     3,810 Downloads   6,137 Views   Citations


Background: Corchorus olitorius leaf contains a significant amount of mucilaginous polysaccharide. It has been generally accepted that the polysaccharides derived from botanical extracts increase skin hydration. Since skin hydration improves skin barrier function, it is one of the most effective treatments for atopic dermatitis (AD). However, other components of botanical extracts other than polysaccharides may influence skin hydration and transepidermal water loss (TEWL). The aim of this study was to evaluate the hydration efficacy and skin barrier protection afforded to the skin after exposure to Corchorus olitorius extract without high-molecular-weight compounds (COEW), such as polysaccharides. Methods: NC/Nga mice possess disrupted skin barrier function, and were used as a model for AD. A stable base cream was supplemented with 0.2% COEW and applied to the dorsal skin of these mice. Skin hydration and TEWL were analyzed after a 14-d period of daily application. AD scores and plasma immunoglobulin E (IgE) concentrations were also investigated. Results: Compared to control mice, mice treated with the COEW cream showed significantly increased skin hydration and reduced TEWL. Plasma IgE concentrations were not affected by the COEW cream, whereas an increase in AD score in NC/Nga mice was prevented because of the application of the COEW cream. Conclusions: COEW has the ability to maintain hydration of the skin, and to prevent the disruption of skin barrier function, which leads to the aggravation of AD. COEW may be used as an adjunct treatment for AD.

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S. Yokoyama, K. Hiramoto, T. Fujikawa, H. Kondo, N. Konishi, S. Sudo, M. Iwashima and K. Ooi, "Skin Hydrating Effects of Corchorus olitorius Extract in a Mouse Model of Atopic Dermatitis," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 4 No. 1, 2014, pp. 1-6. doi: 10.4236/jcdsa.2014.41001.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] A. F. Abu-Hadid, M. Z. El-Shinawy, A. S. El-Bethagy, S. A. Gaafer and M. Medany, “Studies on the Production of Off-Season Jew’s Mallow (Molokhia) in Egypt,” Egyptian Journal of Horticulture, Vol. 21, 1994, pp. 187-193.
[2] S. Zeghichi, S. Kallithraka and A. P. Simopoulos, “Nutritional Composition of Molokhia (Corchorus olitorius) and Stamnagathi (Cichorium spinosum),” World Review of Nutrition & Dietetics, Vol. 91, 2003, pp. 1-21.
[3] Z. A. Zakaria, M. Safarul, R. Valsala, M. R. Sulaiman, C. A. Fatimah, M. N. Somchit and A. M. Mat Jais, “The Influences of Temperature and Naloxone on the Antinociceptive Activity of Corchorus olitorius L. in Mice,” Naunyn-Schmiedeberg’s Archives of Pharmacology, Vol. 372, No. 1, 2005, pp. 55-62.
[4] C. J. Li, S. Y. Huang, M. Y. Wu, Y. C. Chen, S. F. Tsang, J. H. Chyuan and H. Y. Hsu, “Induction of Apoptosis by Ethanolic Extract of Corchorus olitorius Leaf in Human Hepatocellular Carcinoma (HepG2) Cells via a Mitochondria-Dependent Pathway,” Molecules, Vol. 17, No. 8, 2012, pp. 9348-9360.
[5] K. Ohtani, K. Okai, U. Yamashita, I. Yuasa and A. Misaki, “Characterization of an Acidic Polysaccharide Isolated from the Leaves of Corchorus olitorius (Moroheiya),” Bioscience, Biotechnology, and Biochemistry, Vol. 59, No. 3, 1995, pp. 378-381.
[6] M. Kanlayavattanakul, C. Rodchuea and N. Lourith, “Moisturizing Effect of Alcohol-Based Hand Rub Containing Okra Polysaccharide,” International Journal of Cosmetic Science, Vol. 34, No. 3, 2012, pp. 280-283.
[7] B. Futrakul, M. Kanlayavattanakul and P. Krisdaphong, “Biophysic Evaluation of Polysaccharide Gel from Durian’s Fruit Hulls for Skin Moisturizer,” International Journal of Cosmetic Science, Vol. 32, No. 3, 2010, pp. 211-215.
[8] S. E. Dal’Belo, L. R. Gaspar and P. M. Maia Campos, “Moisturizing Effect of Cosmetic Formulations Containing Aloe Vera Extract in Different Concentrations Assessed by Skin Bioengineering Techniques,” Skin Research and Technology, Vol. 12, No. 4, 2006, pp. 241-246. 1111/j.0909-752X.2006.00155.x
[9] M. Fujii, T. Shimizu, T. Nakamura, F. Endo, S. Kohno and T. Nabe, “Inhibitory Effect of Chitosan-Containing Lotion on Scratching Response of Hairless Mice with Atopic Dermatitis-Like Dry Skin,” Bioscience, Biotechnology, and Biochemistry, Vol. 34, No. 12, 2011, pp. 1890-1894.
[10] A. Aioi, H. Tonogaito, H. Suto, K. Hamada, C. R. Ra, H. Ogawa, H. Maibach and H. Matsuda, “Impairment of Skin Barrier Function in NC/Nga Tnd Mice as a Possible Model for Atopic Dermatitis,” British Journal of Dermatology, Vol. 144, No. 1, 2001, pp. 12-18.
[11] M. Lodén, A. C. Andersson and M. Lindberg, “Improvement in Skin Barrier Function in Patients with Atopic Dermatitis after Treatment with a Moisturizing Cream (Canoderm),” British Journal of Dermatology, Vol. 140, No. 2, 1999, pp. 264-267. 02660.x
[12] E. Berardesca and European Group for Efficacy Measurements on Cosmetics and Other Topical Products (EEMCO), “EEMCO Guidance for the Assessment of Stratum Corneum Hydration: Electrical Methods,” Skin Research and Technology, Vol. 3, No. 2, 1997, pp. 126-132. 1111/j.1600-0846.1997.tb00174.x
[13] A. O. Barel and P. Clarys, “Study of the Stratum Corneum Barrier Function by Transepidermal Water Loss Measurements: Comparison between Two Commercial Instruments: Evaporimeter and Tewameter,” Skin Pharmacology, Vol. 8, No. 4, 1995, pp. 186-195. 0211345
[14] D. Y. Leung, R. L. Hirsch, L. Schneider, C. Moody, R. Takaoka, S. H. Li, L. A. Meyerson, S. G. Mariam, G. Goldstein and J. M. Hanifin, “Thymopentin Therapy Reduces the Clinical Severity of Atopic Dermatitis,” Journal of Allergy and Clinical Immunology, Vol. 85, No. 5, 1990, pp. 927-933.
[15] S. Y. Eom, C. B. Chung, Y. S. Kim, J. H. Kim, K. S. Kim, Y. H. Kim, S. H. Park, Y. I. Hwang and K. H. Kim, “Cosmeceutical Properties of Polysaccharides from the Root Bark of Ulmus davidiana var. Japonica,” Journal of Cosmetic Science, Vol. 57, No. 5, 2006, pp. 355-367.
[16] L. F. Eichenfield, A. McCollum and P. Msika, “The Benefits of Sunflower Oleodistillate (SOD) in Pediatric Dermatology,” Pediatric Dermatology, Vol. 26, No. 6, 2009, pp. 669-675. j.1525-1470.2009.01042.x
[17] M. M. McCusker and J. M. Grant-Kels, “Healing Fats of the Skin: The Structural and Immunologic Roles of the Omega-6 and Omega-3 Fatty Acids,” Clinics in Dermatology, Vol. 28, No. 4, 2010, pp. 440-451.
[18] C. H. Yen, Y. S. Dai, Y. H. Yang, L. C. Wang, J. H. Lee and B. L. Chiang, “Linoleic acid Metabolite Levels and Transepidermal Water Loss in Children with Atopic Dermatitis,” Annals of Allergy, Asthma & Immunology, Vol. 100, No. 1, 2008, pp. 66-73.
[19] K. Nakai, K. Yoneda and Y. Kubota, “Oxidative Stress in Allergic and Irritant Dermatitis: From Basic Research to Clinical Management,” Recent Patents on Inflammation & Allergy Drug Discovery, Vol. 6, No. 3, 2012, pp. 202-209.
[20] K. Orita, K. Hiramoto, R. Inoue, E. F. Sato, H. Kobayashi, M. Ishii and M. Inoue, “Strong Exercise Stress Exacerbates Dermatitis in Atopic Model Mice, NC/Nga Mice, while Proper Exercise Reduces It,” Experimental Dermatology, Vol. 19, No. 12, 2010, pp. 1067-1072.
[21] M. Yoshikawa, H. Shimada, M. Saka, S. Yoshizumi, J. Yamahara and H. Matsuda, “Medicinal Foodstuffs. V. Moroheiya. (1): Absolute Stereostructures of Corchoionosides A, B, and C, Histamine Release Inhibitors from the Leaves of Vietnamese Corchorus olitorius L. (Tiliaceae),” Chemical & Pharmaceutical Bulletin, Vol. 45, No. 3, 1997, pp. 464-469.
[22] D. Hayashi, H. Sugaya, T. Ohkoshi, K. Sekizawa, H. Takatsu, T. Shinkai and S. Urano, “Vitamin E Improves Biochemical Indices Associated with Symptoms of Atopic Dermatitis-Like Inflammation in NC/Nga Mice,” Journal of Nutritional Science and Vitaminology, Vol. 58, No. 3, 2012, pp. 161-168.
[23] Y. Soma, M. Kashima, A. Imaizumi, H. Takahama, T. Kawakami and M. Mizoguchi, “Moisturizing Effects of Topical Nicotinamide on Atopic Dry Skin,” International Journal of Dermatology, Vol. 44, No. 3, 2005, pp. 197-202.

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