Antioxidants as effective remedies at hepatotoxic action of carbon tetrachloride

Karlen Hovnanyan, Vardan Mamikonyan, Anahit Margaryan, Kristine Sargsyan, Margarita Hovnanyan, Maria Karagyozyan, Konstantin Karageuzyan

H. Buniatian Institute of Biochemistry, NAS RA, Yerevan, Armenia.
Institute of Molecular Biology, Yerevan, Armenia.
Scientific and Technological Center of Organic and Pharmaceutical Chemistry, NAS RA, Yerevan, Armenia.

DOI: 10.4236/jbpc.2014.51001                

Abstract

The liver, as the central metabolic organ, plays an important role in metabolism of carbohydrates, lipids and proteins. In the environment, there are many hepatotoxic xenobiotics. CCl4 is a free radical toxic for organelles of hepatocytes. The presented work was studying the character of ultrastructural changes in CCl4-intoxicated hepatocytes as well as the tissue after treatment by grape seed extract (GSE), α-tocopherol (α-T). As a result of cell bioremediation effect and reactions against corruptive factors, the liver has a high regeneration ability.

Keywords

CCl4; GSE; α-Tocopherol; Ultrastructural Changes; Intoxicated Hepatocytes; Electron Microscopy

Conflicts of Interest

The authors declare no conflicts of interest.

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