Antioxidants as effective remedies at hepatotoxic action of carbon tetrachloride


The liver, as the central metabolic organ, plays an important role in metabolism of carbohydrates, lipids and proteins. In the environment, there are many hepatotoxic xenobiotics. CCl4 is a free radical toxic for organelles of hepatocytes. The presented work was studying the character of ultrastructural changes in CCl4-intoxicated hepatocytes as well as the tissue after treatment by grape seed extract (GSE), α-tocopherol (α-T). As a result of cell bioremediation effect and reactions against corruptive factors, the liver has a high regeneration ability.

Share and Cite:

Hovnanyan, K. , Mamikonyan, V. , Margaryan, A. , Sargsyan, K. , Hovnanyan, M. , Karagyozyan, M. and Karageuzyan, K. (2014) Antioxidants as effective remedies at hepatotoxic action of carbon tetrachloride. Journal of Biophysical Chemistry, 5, 1-4. doi: 10.4236/jbpc.2014.51001.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Dzhivanyan, K.A. and Adamyan, N.V. (2001) About features of ultrastructure of a liver of birds in norm and after partial hepatoctomy. The Russian Morphological Sheets, Moscow, 3-4, 26-27.
[2] Fausto, N. and Campbell, J.S. (2003) The role of hepatocytes and oval cells in liver regeneration and repopulation. Mechanisms of Development, 120, 117-130.
[3] Loginov, A.S. and Block, Yu.E. (1987) Chronical hepatitis and liver cirrhosis. Medicine, 272.
[4] Powell, E.E., Jonsson, J.R. and Clouston, A.D. (2005) Steatosis: Cofactor in other liver diseases. Hepatology, 42, 5-13.
[5] Simonyan, А.А., Margaryan, А.S., Hovnanyan, К.О., Asatryan, R.G. and Hov?nanyan, М.К. (2007) Effect of antioxi?dants on white rats with liver intoxica?tion induced by carbon tetrachloride: Ul?trastructural analysis. Proceedings of the International Symposium under the Aegis of UNESCO “Problems of Biochemis?try, Molecular and Radiation Biology and Genetics”, Yerevan, 2007, 74-75.
[6] Craciun, C., Ardelan, A., Ciobanu, C., Rusu, M.A., Puica, C., Tamas, M. and Craciun, V. (2004) Structural-funtional studies regarding the effect of Berberia vulgaris extract on rat intoxicated liver. Proceedings of 13th European Microscopy Congress, Antwerp, 3, 463-464.
[7] Sabatini, D.D., Bensch, K. and Barnett, R.J. (1963) Cyto-chemistry and electron microscopy—The preservation of cellula?r ultrastructure and enzymatic activity by aldehyde fixation. The Journal of Cell Biology, 17, 19-58.
[8] Venable, J.H. and Coggeshall, R. (1965) A simplified lead citrate stain for use in electron microscopy. The Journal of Cell Biology, 25, 407-408.
[9] Sarkisov, D.S. (1970) Regeneration and its clinical significance. Medi?cine, 281.

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.