Adult Acute T Cell Leukemia Presenting as Acute Renal Failure, Parotid Swelling and Loss of Vision

Usha  , Deepa Santhosh, Sandeep Kumar, R. G. Singh, Jai Prakash

Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Varanasi. India.
Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

DOI: 10.4236/ijcm.2014.51007                

Abstract

A rare case of T cell acute lymphoblastic leukemia presenting with loss of vision, parotid swelling, hematuria and acute renal failure has been presented in a 40-year-old male. Acute T cell Lymphoblastic Leukemia should also be kept in differential diagnosis of hematuria, acute renal failure and loss of vision.

Keywords

Acute Renal Failure; Acute T Lymphoblastic Leukemia; Adult; Hematuria; Parotid Gland Enlargement; Ocular Manifestation

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	O. M. Suriya and A. Aleem, “Frank Hematuria as the Presentation Feature of Acute Leukemia,” Saudi Journal of Kidney Diseases and Transplantation, Vol. 21, No. 5, 2010, pp. 940-942.
[2]	T. Singh, “Atlas and Text of Hematology,” Avichal Publishing Company, New Delhi, 2010, p. 136.
[3]	J. Trachsler, A. Gaspert, M. Previsdomini, R. P. Wuthrich and T. Fehr, “Massive Uric Acid Nephrolithiasis with Progressive Renal Failure Due to Spontaneous Tumour Lysis Syndrome,” NDT Plus, Vol. 1, No. 5, 2008, pp. 307-309. http://dx.doi.org/10.1093/ndtplus/sfn133
[4]	N. Gilboa, G. M. Lum and R. E. Urizar, “Early Renal Involvement in Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphoma in Children,” Journal of Urology, Vol. 129, No. 2, 1983, pp. 364-367.
[5]	K. P. Harris, J. M. Hattersley, J. Feehally and J. Walls, “Acute Renal Failure Associated with Haematological Malignancies: A Review of 10 Years Experience,” European Journal of Haematology, Vol. 47, No. 2, 1991, pp. 119-122. http://dx.doi.org/10.1111/j.1600-0609.1991.tb00133.x
[6]	G. Martini, R. Dall’Amico, L. Murer, G. Montini, A. D’Avino and G. Zacchello, “Hemolytic-Uremic Syndrome as a Presenting form of Acute Lymphocytic Leukemia,” Annals of Hematology, Vol. 79, No. 8, 2000, pp. 452-454. http://dx.doi.org/10.1007/s002770000174
[7]	H. H. Hsu, Y. L. Chan and C. C. Huang, “Acute Spontaneous Tumor Lysis Presenting with Hyperuricemic Acute Renal Failure: Clinical Features and Therapeutic Approach,” Journal of Nephrology, Vol. 17, No. 1, 2004, pp. 50-56.
[8]	S. Z. Usmani, Z. Shahid, H. Saleh and K. A. Nasser, “Myeloid Sarcoma Presenting with Acute Renal Failure and Bilateral Ureteral Obstruction: A Case Report and Review of the Literature,” American Journal of the Medical Sciences, Vol. 334, No. 2, 2007, pp. 136-138 http://dx.doi.org/10.1097/MAJ.0b013e31812e978b
[9]	Y. Basaran, S. Sayin, G. Erdem, O. Nevruz and A. U. Ural, “A Rare Initial Manifestation of Acute Lymphocytic Leukemia: Bilaterally Enlarged Kidneys and Liver,” Internal Medicine, Vol. 48, No. 17, 2009, pp. 1541-1544. http://dx.doi.org/10.2169/internalmedicine.48.2395
[10]	W. M. Suh, Z. A. Wainberg, S. de Vos, A. H. Cohen, I. Kurtz and M. K. Nguyen, “Acute Lymphoblastic Leukemia Presenting as Acute Renal Failure,” Nature Clinical Practice Nephrology, Vol. 3, No. 2, 2007, pp. 106-110. http://dx.doi.org/10.1038/ncpneph0400
[11]	V. Agarwal, R. Mondal, N. Krishnani and S. Nityanand, “Parotid Gland Enlargement as a Presenting Manifestation of Acute Lymphoblastic Leukemia,” JK Science, Vol. 7, No. 3, 2005, pp. 167-168.
[12]	T. Sharma, J. Grewal, S. Gupta and P. I. Murray, “Ophthalmic Manifestations of Acute Leukaemias: The Ophthalmologist’s Role,” Eye, Vol. 18, No. 7, 2004, pp. 663-672. http://dx.doi.org/10.1038/sj.eye.6701308