Clinical Pathological Correlation Quiz: A 7-Month-Old Girl with Congenital Neutropenia and Increased Bone Morrow “Blasts”

Ruchika Sharma, Jessica A. Hemminger, Samir B. Kahwash

Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, Columbus, USA.
Department of Pathology and Laboratory Medicine, Wexner Medical Center at the Ohio State University, Columbus, USA.
Division of Hematology/Oncology, Nationwide Children’s Hospital, Columbus, USA.

DOI: 10.4236/ojpathology.2014.41001                

Abstract

Persistent Neutropenia in a child presents a wide differential diagnosis, spanning the spectrum of benign disorders (such as congenital neutropenia, cyclic neutropenia, etc.) to malignant processes (such as myelodysplasia or acute leukemia). The morphologic findings in the bone marrow of a patient with neutropenia may show considerable overlap with those seen in hematopoietic malignancies. We present herein a case that demonstrates this overlap and discuss features that can help in avoiding diagnostic pitfalls.

Keywords

Neutropenia; Hematogones; ELANE Mutation; Acute Leukemia

Conflicts of Interest

The authors declare no conflicts of interest.

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