Hypertension Unusual Cause


We expose a case of a woman with hypertension and hypokalemia. The differential diagnosis should include primary hyperaldosteronism, diuretics or lazantes intake, secondary hyperaldosteronism. In this patient, additional tests performed show no cause of hormonal disruption and the whole picture is due to a high intake of licorice. Glycyrrhetinic acid, the active component of licorice, inhibits renal IIbeta-hydroxisteroid dehydrogenase. This allows cortisol to stimulate mineralocorticoid receptors. Licorice ingestion should be considered in the differential diagnosis of hypertension with hypokalemia.

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A. Hernández Cascales, A. Torres, M. Ibáñez Gil, P. Alarcón, A. López Ruiz, M. Hellín Gil and J. Barrancos, "Hypertension Unusual Cause," Pharmacology & Pharmacy, Vol. 5 No. 1, 2014, pp. 1-3. doi: 10.4236/pp.2014.51001.

Conflicts of Interest

The authors declare no conflicts of interest.


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