Quantitative regulation of peripheral leukocyte by light exercise and tailored scale for assessment

Nobuo Yamaguchi, Rui Chen, Kazuhiro Okamoto, Takafumi Takei, Misao Tsubokawa, Daisuke Sakamoto, Xiufeng Jia, Wenhan Wan, Tsugiya Murayama

Deaprtment of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.
Department of Heart Surgery, Kanazawa Medical University, Himi Municipal Hospital, Himi City, Japan.
Department of Rehabilitation, Kanazawa Medical University, Uchinada-machi, Japan.
Ishikawa Medicinal Products Research Center, Kanazawa, Japan;.
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

DOI: 10.4236/oji.2013.34022                

Abstract

Two primary defense systems develop in vertebrates, innate and adaptive. However, every individual exposes to the risk of immunodeficiency in daily life with both internal and external stimuli. In this report, we tried to report two different stimuli for regulating the immune system modulate and discussed how we can compare and select each menu by evidence-based manner more than VAS. In a series of investigation, we have assessed the various leukocyte regulating menus such as hot spring hydrotherapy, acupuncture & moxibution, light walking, independent of the western medicine. In this report, we try to compare the regulatory effect of light exercise under the influence of hypothalamus system. Their effects of elements were evaluated by the total number of peripheral leukocyte, its subsets, granulocyte and lymphocyte ratio. The regulative effects were confirmed also by other menu such as hydrotherapy, acupuncture, walking etc. However, by simply comparing the group before with the group after CAM, we cannot catch the real regulatory effect by each menu. So we tried to show the effect by trying to indicate the constitution/condition dependent manner. The effect was not uniform to each individual but it was dependent on each condition/constitution before the start of the exercise. This was one of the main purposes of this report for summarizing that it is important to regulate the number and levels of each factor as ideal value. In other words, the regulation of each factor affected under the hypothalamus system is regulated with each constitution, under the influence of daily circumstances. The mode of regulation was the same in each menu, indicating the higher level was down regular and lower level was up regular. Moreover, each vector of change was reversely correlated to the value of the day before. The other purpose of this study was designed to establish the regulatory effect of this light exercise which is not limited in the number of leukocyte in peripheral. Light exercise for a short duration was expected to influence the immune system in the blood quantitatively. Preparing two modes of impact for walking, 4 mets by walking exhibited more effective than that of 8 mets. We tried to discuss the suitable scale to know the best intensity to regulate whole body system other than VAS judgment.

Keywords

Light Exercise; Walking; Peripheral Leukocyte; Leukocyte Subsets Ratio; Metabolic Rate

Conflicts of Interest

The authors declare no conflicts of interest.

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