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Quantitative regulation of peripheral leukocyte by light exercise and tailored scale for assessment

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DOI: 10.4236/oji.2013.34022    3,032 Downloads   4,907 Views   Citations

ABSTRACT

Two primary defense systems develop in vertebrates, innate and adaptive. However, every individual exposes to the risk of immunodeficiency in daily life with both internal and external stimuli. In this report, we tried to report two different stimuli for regulating the immune system modulate and discussed how we can compare and select each menu by evidence-based manner more than VAS. In a series of investigation, we have assessed the various leukocyte regulating menus such as hot spring hydrotherapy, acupuncture & moxibution, light walking, independent of the western medicine. In this report, we try to compare the regulatory effect of light exercise under the influence of hypothalamus system. Their effects of elements were evaluated by the total number of peripheral leukocyte, its subsets, granulocyte and lymphocyte ratio. The regulative effects were confirmed also by other menu such as hydrotherapy, acupuncture, walking etc. However, by simply comparing the group before with the group after CAM, we cannot catch the real regulatory effect by each menu. So we tried to show the effect by trying to indicate the constitution/condition dependent manner. The effect was not uniform to each individual but it was dependent on each condition/constitution before the start of the exercise. This was one of the main purposes of this report for summarizing that it is important to regulate the number and levels of each factor as ideal value. In other words, the regulation of each factor affected under the hypothalamus system is regulated with each constitution, under the influence of daily circumstances. The mode of regulation was the same in each menu, indicating the higher level was down regular and lower level was up regular. Moreover, each vector of change was reversely correlated to the value of the day before. The other purpose of this study was designed to establish the regulatory effect of this light exercise which is not limited in the number of leukocyte in peripheral. Light exercise for a short duration was expected to influence the immune system in the blood quantitatively. Preparing two modes of impact for walking, 4 mets by walking exhibited more effective than that of 8 mets. We tried to discuss the suitable scale to know the best intensity to regulate whole body system other than VAS judgment.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Yamaguchi, N. , Chen, R. , Okamoto, K. , Takei, T. , Tsubokawa, M. , Sakamoto, D. , Jia, X. , Wan, W. and Murayama, T. (2013) Quantitative regulation of peripheral leukocyte by light exercise and tailored scale for assessment. Open Journal of Immunology, 3, 175-183. doi: 10.4236/oji.2013.34022.

References

[1] Davis, B.K. and Gill, T.J. (1975) Decreased antibody response in the offspring of immunized high responder rats. The Journal of Immunology, 115, 1166-1168.
[2] Miyazaki, Y., Leeuwen, L.V. and Leeuwen, G.V. (1977) Retrolental fibroplasia: A continuing dilemma for the pediatrician. Clinical Pediatrics, 16, 1091-1092
[3] Kishida, k., Miyazaku, S., Take, H., Fujimoto, T., Shi, H., Sasaki, K. and Goya N. (1978) Granial irradiation and lymphocyte subpopulation in acute lymphatic leukemia. Journal of Pediatrics, 92, 785-786. http://dx.doi.org/10.1016/S0022-3476(78)80155-3
[4] Wenhan, W., Shimizu, S., Ikawa, H., Sugiyama, K., Yamaguchi, N. (2002) Maternal cell traffic bounds for immune modulation: tracking maternal H-2 alleles in spleens of baby mice by DNA fingerprinting. Immunology, 107, 261-267.
[5] Murgita, R.A. and Tomasi, Jr. T.B. (1975) Suppression of the immune response by alpha-fetoprotein. The Journal of Experimental Medicine, 141, 269-286. http://dx.doi.org/10.1084/jem.141.2.269
[6] Paul, G., Margaret, S., Liew, Y.F. and Allan, M.M. (1995) CD4+ but not CD8+ T cells are required for the induction of oral tolerance. International Immunology, 7, 501-504. http://dx.doi.org/10.1093/intimm/7.3.501
[7] Fujii, Y., Li, A.-L, Kohno, H. and Yamaguchi, N. (1993) Major histocompatibility complex restriction of maternally induced suppression in young adult mice. Immunology, 80, 337-342.
[8] Zoeller, M. (1998) Tolerization during pregnancy: Impact on the development of antigen-specific help and suppression. European Journal of Immunology, 18, 1937-1943. http://dx.doi.org/10.1002/eji.1830181211
[9] Auerback, R. and Clark, S. (1975) Immunological tolerance: Transmission from mother to offspring. Science, 189, 811-813. http://dx.doi.org/10.1126/science.1162355
[10] Shinka, S., Dohi, Y., Komatsu, T., Natarajan, R. and Amano, T. (1974) Immunological unresponsiveness in mice. I. Immunological unresponsiveness induced in embryonic mice by maternofetal transfer of human-globulin. Biken Journal, 17, 59-72.
[11] Aase, J.M., Noren, G.R., Reddy, D.V. and Geme Jr., J.W. (1972) Mumps-virus infection in pregnant women and the immunologic response of their offspring. The New England Journal of Medicine, 286, 1379-1382. http://dx.doi.org/10.1056/NEJM197206292862603
[12] Cramer, D.V., Kunz, H.W. and Gill III, T.J. (1974) Immunologic Sensitization Prior to Birth. American Journal of Obstetrics & Gynecology, 120, 431-439.
[13] Yamaguchi, N., Shimizu, S. and Izumi, H. (2004) Hydrotherapy can Modulate Peripheral Leukocytes: An Approach to Alternative Medicine. Complementary and Alternative Approaches to Biomedicine (Edwin L. Cooper, Nobuo Yamaguchi), Kluwer Academic/Plenum Publishers, New York, 239-251.
[14] Matsuno, H., Wang, X.-X., Wan, W., Matsui, K., Ohkawa, S., Sugiyama, T., Kohno, H., Shimizu, S., Lai, J.E. and Yamaguchi, N. (1999) Variation of cell populations taking charge of immunity in human peripheral blood following hot spring hydrotherapy qualitative discussion. The Journal of Japanese Association of Physical Medicine, Balneology and Climatology, 62, 135-140.
[15] Matsuba, S. (2004) Complementary and alternative approaches to biomedicine. eCAM, 3,345-348
[16] Wan, W., Li, A.-L., Izumi, H., Kawada, N., Arai, M., Takada, A., Taru, A., Hashimoto, H. and Yamaguchi, N. (2002) Effect of acupuncture on leukocyte and lymphocyte subpopulation in human peripheral blood qualitative discussion. The Journal of Japanese Association of Physical Medicine, Balneology and Climatology, 65, 207-211.
[17] Wang, X.-X., Katoh, S. and Liu, B.-X. (1998) Effect of physical exercise on leukocyte and lymphocyte subpopulations in human peripheral blood. Cytometry Research, 8, 53-61.
[18] Kitada, Y., Wan, W., Matsui, K., Shimizu, S. and Yamaguchi, N. (2000) Regulation of peripheral white blood cells in numbers and functions through hot-spring bathing during a short term studies in control experiments. Journal of Japanese Society Balneology Climatology Physiological Medicine, 63, 151-164.
[19] Yamaguchi, N., Takahashi, T., Sugita, T., Ichikawa, K., Sakaihara, S., Kanda, T., Arai, M. and Kawakita, K. (2007) Acpuncture regulates leukocyte subpopulations in human peripheral blood. eCAM, 4, 447-453.
[20] Yamaguchi, N., Shimizu, S. and Izumi, H. (2004) Hydrotherapy can modulate peripheral leukocytes: An approach to alternative medicine. Complementary and Alternative Approaches to Biomedicine, 546, 239-251. http://dx.doi.org/10.1007/978-1-4757-4820-8_18
[21] Bylund, D.B., Eikenberg, D.C., Hieble, J.P., Langer, S.Z., Lefkowitz, R.J. and Minneman, K.P. (1994) Intenational union of pharmacology nomenclature of adrenoceptors. Pharmacological Review, 46, 121-136.
[22] Ignarro, L.J., Colombo, C. (1973) Enzyme release from polymorphonuclear leukocyte lysosomes: Regulation by autonomic drugs and cyclic nucleotides. Science, 180, 1181-1183. http://dx.doi.org/10.1126/science.180.4091.1181
[23] Dulis, B.H. and Wilson, I.B. (1980) The β-adrenergic receptor of live human polymorphonuclear leukocytes. Journal of Biological. Chemistry, 255, 1043-1048.
[24] Ostberg, J.R., Patel, R. and Repasky, E.A. (2000) Regulation of immune activity by mild (fever-range) whole body hyperthermia: effect on epidermal Langerhans cells. Cell stress chaperones, 5, 458-461. http://dx.doi.org/10.1379/1466-1268(2000)005<0458:ROIABM>2.0.CO;2
[25] Huang, Y.H., Haegerstrand, A. and Frostegard, J. (1996) Effect of in vitro hyperthermia on proliferative responses and lymphocyte activity. Clinical Experimental Immunology, 103, 61-66. http://dx.doi.org/10.1046/j.1365-2249.1996.00932.x
[26] Mats, H., Orion, E. and Wolf, R. (2003) Balneotherapy in Dermatology. Dermatological Therapy, 16, 132-140. http://dx.doi.org/10.1046/j.1529-8019.2003.01622.x
[27] Elenkov. I.J. and Crousos, G.P. (1999) Stress hormones, Th1/Th2 patterns, pro/anti-inflammatory cytokines and susceptibility to disease. Trends in Endocrinology & Metabolism, 10, 359-368. http://dx.doi.org/10.1016/S1043-2760(99)00188-5
[28] Abo, T. and Kumagai, T. (1978) Studies of surface immunoglobulins on human B lymphocytes. Physiological variations of Sig+ cells in peripheral blood. Clinical Experimental Immunology, 33, 441-452.
[29] Sanders, V.M., Baker, R.A., Ramer-Quinn, D.S., Kasprowicz, D.J., Fuchs, B.A., and Street, N.E. (1997) Differential expression of the β2-adrenaergic receptor by Th1 and Th2 clones. Journal of. Immunology, 158, 4200-4210.
[30] Abo, T., Kawate, T., Itoh, K. and Kumagai, K. (1981) Studies on the bioperiodicity of the immune response. I. Circadian rhythms of human T, B and K cell traffic in the peripheral blood. Journal of. Immunology, 126, 1360-1363.
[31] Maisel, A.S., Harris, T., Rearden, C.A. and Michel, M.C. (1990) Beta-adrenergic receptors in lymphocyte subsets after exercise. Alterations in normal individuals and patients with congestive heart failure. Circulation, 82, 2003-2010. http://dx.doi.org/10.1161/01.CIR.82.6.2003
[32] Suzuki, S., Toyabe, S., Moroda, T., Tada, T., Tsukahara, A., Iiai, T. (1997) Circadian rhythm of leukocytes and lymphocytes subsets and its possible correlation with the function of the autonomic nervous system. Clinical Experimental Immunology, 110, 500-508. http://dx.doi.org/10.1046/j.1365-2249.1997.4411460.x
[33] Landmann, R.M.A., Muller, F.B., Perini, C., Wesp, M., Erne, P. and Buhler, F.R. (1984) Changes of immunoregulatory cells induced by psychological and physical stress: Relationship to plasma catecholamines. Clinical Experimental Immunology, 58, 127-135.

  
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