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Synthesis and Evaluation of 2-Amino-4H-Pyran-3-Carbonitrile Derivatives as Antitubercular Agents

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DOI: 10.4236/ojmc.2013.34015    5,150 Downloads   8,682 Views   Citations


A series of 2-amino-4H-pyran-3-carbonitrile derivatives were designed and synthesized. Their antitubercular activities
were evaluated against autoluminescent M. tuberculosis H37Ra and standard strain M. tuberculosis H37Rv. No obvious
antitubercular activities could be observed (MIC > 10 ug/mL). The results are in sharp contrast with the previously reported

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

C. Chen, M. Lu, Z. Liu, J. Wan, Z. Tu, T. Zhang and M. Yan, "Synthesis and Evaluation of 2-Amino-4H-Pyran-3-Carbonitrile Derivatives as Antitubercular Agents," Open Journal of Medicinal Chemistry, Vol. 3 No. 4, 2013, pp. 128-135. doi: 10.4236/ojmc.2013.34015.


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