Piericidins, Novel Quorum-Sensing Inhibitors against Chromobacterium violaceum CV026, from Streptomyces sp. TOHO-Y209 and TOHO-O348

Kazuhiro Ooka, Atsushi Fukumoto, Tomoe Yamanaka, Kanako Shimada, Ryo Ishihara, Yojiro Anzai, Fumio Kato

Department of Microbiology, School of Pharmaceutical Sciences, Toho University, Chiba, Japan.

DOI: 10.4236/ojmc.2013.34012                

Abstract

Piericidin A1, 3’-rhamnopiericidin A1, and a novel compound piericidin E, a new quorum-sensing (QS) inhibitor
against Chromobacterium violaceum CV026, were isolated from the culture broth of Streptomyces sp. QS is well
known as a microbial signaling system and controls certain types of gene expression resulting in bioluminescence,
biofilm formation, swarming motility, antibiotic biosynthesis, and virulence factor production. C. violaceum CV026 is
commonly used to determine qualitative and quantitative QS activity. The structures of piericidin derivatives were characterized,
and their QS activities were determined.

Keywords

Piericidin A1; 3’-Rhamnopiericidin A1; Piericidin E; Quorum-Sensing Inhibitor; Chromobacterium violaceum CV026; N-Acylhomoserinlactone

Conflicts of Interest

The authors declare no conflicts of interest.

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