Piericidins, Novel Quorum-Sensing Inhibitors against Chromobacterium violaceum CV026, from Streptomyces sp. TOHO-Y209 and TOHO-O348


Piericidin A1, 3’-rhamnopiericidin A1, and a novel compound piericidin E, a new quorum-sensing (QS) inhibitor
against Chromobacterium violaceum CV026, were isolated from the culture broth of Streptomyces sp. QS is well
known as a microbial signaling system and controls certain types of gene expression resulting in bioluminescence,
biofilm formation, swarming motility, antibiotic biosynthesis, and virulence factor production. C. violaceum CV026 is
commonly used to determine qualitative and quantitative QS activity. The structures of piericidin derivatives were characterized,
and their QS activities were determined.

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K. Ooka, A. Fukumoto, T. Yamanaka, K. Shimada, R. Ishihara, Y. Anzai and F. Kato, "Piericidins, Novel Quorum-Sensing Inhibitors against Chromobacterium violaceum CV026, from Streptomyces sp. TOHO-Y209 and TOHO-O348," Open Journal of Medicinal Chemistry, Vol. 3 No. 4, 2013, pp. 93-99. doi: 10.4236/ojmc.2013.34012.

Conflicts of Interest

The authors declare no conflicts of interest.


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