The Synergy of Combined Use of DMSO and Bronsted Acid (Ionic Liquid) as a Catalyst Part I: Efficient Niementowski Synthesis of Modified Quinazolinones

Muthu K. Kathiravan, Rajeshwar R. Jalnapurkar, Trupti S. Chitre, Riyaj S. Tamboli, Kumar V. Srinivasan

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DOI: 10.4236/gsc.2011.11003                

Abstract

A new rapid and versatile approach using Ionic liquid/DMSO as a chemical reagent for the synthesis of fused heterocyclic compounds in a highly efficient way is described. This method offers the advantages of proceeding in neutral conditions, giving high to excellent isolated yields (83–92%) for Niementowski synthesis with easy workup procedure. The inherent Bronsted acidity of ionic liquid and high polarity of both IL and DMSO resulted in a significant enhancement in the reaction rate.

Keywords

Ionic Liquids, DMSO, Niementowski

Conflicts of Interest

The authors declare no conflicts of interest.

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