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Survival in Primary Carcinoma of the External and Middle Ear Is Strongly Dependent on Stage at Diagnosi

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DOI: 10.4236/ijohns.2013.26046    3,301 Downloads   4,833 Views   Citations

ABSTRACT

Conclusion: Early-stage detection of temporal bone carcinoma improves the survival rate. When detected at an advanced stage, predicted prognosis is poor even with a combination of surgery, radiotherapy and chemotherapy. Objectives: We evaluated treatment strategies and survival rates in cases of carcinomas of the external and middle ear. Method: Retrospective review of patients treated at Ehime University Hospital during the 32 years from 1977 to 2008. Subjects were 41 patients, consisting of 21 men and 20 women with a mean age of 63.2 years. Modified Pittsburgh staging system: stage I in 11 cases (27%), stage II in 4 (10%), stage III in 6 (15%) and stage IV in 20 (49%). Histopathology: squamous cell carcinoma (SCC) in 35 cases, adenoid cystic carcinoma (ACC) in 3, and adenocarcinoma (AC) in 3. Thirty-eight patients were treated by surgery. Radiation was added postoperatively in 23 patients. Three patients were treated by chemoradiotherapy. Results: The survival rate of carcinomas detected at an advanced stage was poor with a disease-specific 5-year survival rate of 100% in early-stage disease (stage I and II) versus 20.8% in stage III and 27.5% in stage IV disease, irrespective of histopathology of the tumor.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

T. Ugumori, J. Hyodo, N. Hato and K. Gyo, "Survival in Primary Carcinoma of the External and Middle Ear Is Strongly Dependent on Stage at Diagnosi," International Journal of Otolaryngology and Head & Neck Surgery, Vol. 2 No. 6, 2013, pp. 221-227. doi: 10.4236/ijohns.2013.26046.

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