Human photosynthesis, the ultimate answer to the long term mystery of Kleiber’s law or E = M3/4: Implication in the context of gerontology and neurodegenerative diseases
Gjumrakch Aliev, Arturo Solís-Herrera, Yi Li, Yury G. Kaminsky, Nikolay N. Yakhno, Vladimir N. Nikolenko, Andrey A. Zamyatnin Jr., Valery V. Benberin, Sergey O. Bachurin
Department of Anatomy, First Moscow State Medical University, Moscow, Russian Federation.
Department of Neurological Disorders, First Moscow State Medical University, Moscow, Russian Federation.
Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russian Federation.
Medical Center of the Administration of the President of the Republic of Kazakhstan, Astana, Kazakhstan.
Russian Academy of Sciences, Institute of Theoretical and Experimental Biophysics, Pushchino, Russian Federation.
“GALLY” International Biomedical Research Consulting LLC, San Antonio, USA.
Human Photosynthesis Study Center, Pulgas Pandas Sur, México.
Institute of Molecular Medicine, First Moscow State Medical University, Moscow, Russian Federation.
Department of Human Sciences, Texas A&M University-Kingsville, Kingsville, USA.
DOI: 10.4236/ojpsych.2013.34045   PDF    HTML     5,953 Downloads   8,650 Views   Citations

Abstract

Kleiber’s Law or E = M3/4 is a mathematical expression known since 1932 that outlines the relationship between mass (biomass) and the use of energy. It is compelling because it supports a long standing observation that larger animals appear to use energy more efficiently than smaller ones. For example, an elephant’s weight is 200,000 times of a mouse, but uses only about 10,000 fold energy; thus a cat, having a mass of about 100 times of a mouse, only spends roughly 33 fold energy. In other words, the bigger you are, the less energy per gram of tissue you actually need to stay alive. Many facts pertaining to animal size call for a rational explanation. This paper takes into account that the fascinating relationship between mass and energy use for any living thing is governed strictly by a mathematical universal formula across all living species, operating in the tiniest of bacteria to the biggest of whales and sequoia tress. For the first time, we report a capacity for the mammal eukaryotic cell to split, break or dissociate water molecules through melanin. Even though E = M3/4 was discovered eight decades ago, no proper satisfactory explanation exists. Nevertheless, our multiyear detailed study on the “Human Photosynthesis” or first found in the human retina and later in all eukaryotic cells, may finally unravel this mystery, namely, the bigger you are the more surface area you have to absorb electromagnetic radiation and the more potential exists to use that electromagnetic radiation spectra to perform work. We propose a future application of this theory in the context of human diseases, especially age-related disorders, such as retinopathy, cerebrovascular and Alzheimer disease and these implications may not only foster a better understanding of the pathobiology of these devastating diseases but also develop much more effective therapies in the foreseeable future.

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Aliev, G. , Solís-Herrera, A. , Li, Y. , Kaminsky, Y. , Yakhno, N. , Nikolenko, V. , Zamyatnin Jr., A. , Benberin, V. and Bachurin, S. (2013) Human photosynthesis, the ultimate answer to the long term mystery of Kleiber’s law or E = M3/4: Implication in the context of gerontology and neurodegenerative diseases. Open Journal of Psychiatry, 3, 408-421. doi: 10.4236/ojpsych.2013.34045.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Heusner, A.A. (1985) Body size and energy metabolism. Annual Review of Nutrition, 5, 267-293. http://dx.doi.org/10.1146/annurev.nu.05.070185.001411
[2] West, G.B. and Brown, J.H. (2005) The origin of allometric scaling laws in biology from genomes to ecosystems: towards a quantitative unifying theory of biological structure and organization. The Journal of Experimental Biology, 208, 1575-1592. http://dx.doi.org/10.1242/jeb.01589
[3] Reich, P.B., Tjoelker, M.G., Machado, J.L. and Oleksyn, J. (2006) Universal scaling of respiratory metabolism, size and nitrogen in plants. Nature, 439, 457-461. http://dx.doi.org/10.1038/ nature04282
[4] West, G.B., Woodruff, W.H. and Brown, J.H. (2002) Allometric scaling of metabolic rate from molecules and mitochondria to cells and mammals. Proceedings of the National Academy of Sciences of USA, 99, 2473-2478. http://dx.doi.org/10.1073/pnas.012579799
[5] Wang, Z., O’Connor, T.P., Heshka, S. and Heymsfield, S.B. (2001) The reconstruction of Kleiber’s law at the organ-tissue level. Journal of Nutrition, 131, 2967-2970.
[6] Smil, V. (2000) Laying down the law. Nature, 403, 597. http://dx.doi.org/10.1038/35001159
[7] Hulbert, A.J. and Else, P.L. (2000) Mechanisms underlying the cost of living in animals. Annual Review of Physiology, 62, 207-235. http://dx.doi.org/10.1146/annurev.physiol.62.1.207
[8] West, G.B., Brown, J.H. and Enquist, B.J. (1999) The fourth dimension of life: Fractal geometry and allometric scaling of organisms. Science, 284, 1677-1679. http://dx.doi.org/10.1126/science. 284.5420.1677
[9] Proctor, P.H. and McGinness, J.E. (1986) The function of melanin. Archives of Dermatology, 122, 507-508. http://dx.doi.org/10.1001/archderm.1986.01660170031013
[10] Szoke, A., Scott, W.G. and Hajdu, J. (2003) Catalysis, evolution and life. FEBS Letters, 553, 18-20. http://dx.doi.org/10.1016/S0014-5793(03)01008-1
[11] Laughlin, R.B. and Pines, D. (2000) The theory of everything. Proceedings of the National Academy of Sciences of USA, 97, 28-31. http://dx.doi.org/10.1073/pnas.97.1.28
[12] de Meis, L. (2001) Uncoupled ATPase activity and heat production by the sarcoplasmic reticulum Ca2+-ATPase. Regulation by ADP. The Journal of Biological Chemistry, 276, 25078-25087. http://dx.doi.org/10.1074/jbc.M103318200
[13] Halonen, P., Baykov, A.A., Goldman, A., Lahti, R. and Cooperman, B.S. (2002) Single-turnover kinetics of Saccharomyces cerevisiae inorganic pyrophosphatase. Biochemistry, 41, 12025-12031.
http://dx.doi.org/10.1021/bi026018z
[14] Aliev, G. (2013) The role of oxidative stress, mitochondria failure, and cellular hypoperfusion in the context of Alzheimer disease: Past, present and future. Nova Science Publishers, Inc., New York, 1-426. https://www.novapublishers.com/catalog/product_info.php?products_id=31801
[15] Dadachova, E., Bryan, R.A., Huang, X., Moadel, T., Schweitzer, A.D., Aisen, P., Nosanchuk, J.D. and Casadevall, A. (2007) Ionizing radiation changes the electronic properties of melanin and enhances the growth of melanized fungi. PLoS One, 2, e457. http://dx.doi.org/10.1371/journal.pone.0000457
[16] Meredith, P. and Sarna, T. (2006) The physical and chemical properties of Eumelanin. Pigment Cell Research, 19, 572-594. http://dx.doi.org/10.1111/j.1600-0749.2006.00345.x
[17] Blum, J.J. (1977) On the geometry of four-dimensions and the relationship between metabolism and body mass. Journal of Theoretical Biology, 64, 599-601. http://dx.doi.org/10.1016/0022-5193 (77)90292-2
[18] Schmidt-Nielsen, K. (1984) Scaling, why is animal size so important. Cambridge University Press, Cambridge.
[19] Aliev, G. (2013) Oxidative stress induced cellular hypoperfusion, mitochondrial DNA overproliferation and deletion in context of neurodegeneration and cancer. Abstract Book. International IX Congress “Neuroscience for Medicine and Psychology”, Sudak, 3-13 June 2013, 57-58.
[20] Aliev, G. (2011) Oxidative stress in neurodegeneration and cancer. Gen-T. The EuroEspes Journal, 8, pp. 36-37.
[21] Aliev, G., Palacios, H.H., Gasimov, E., Gokhman, D., Leszek, J., Obrenovich, M.E., Bragin, V. and Solís-Herrera, A. (2010) Targeting oxidative stress induced brain hypometabolism and brain mitochondrial failure as a new and effective strategies for the prevention and treatment of cognitive decline in elderly demented/depressed patients and AD: New scents on the trail? Alzheimer’s & Disease, 6, 2010, S579.
[22] Aliev, G., Palacios, H.H., Gasimov, E., Gokhman, D., Leszek, J., Obrenovich, M.E., Bragin, V. and Solís-Herrera, A. (2010) Oxidative stress-induced mitochondrial failure, cellular hypoperfusion and brain hypometabolism underlay the pathophysiology of Alzheimer disease and offer new and successful targets for treatment. Revista de Neuropsiquiatria y Neurociencia Cognitiva, 9, 13.

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