The COP9 Signalosome Controls Adipocyte Differentiation by Regulating CHOP Protein Stability

Abstract Full-Text HTML Download Download as PDF (Size:38KB) PP. 192-193
DOI: 10.4236/eng.2012.410B050    3,255 Downloads   3,986 Views  

ABSTRACT

Obesity is a serious health problem of our time. Dysfunction of adipogenesis, the differentiation of adipocytes, is a hallmark of obesity. Therefore here we investigate the role of the COP9 signalosome and of CHOP in the differentiation of LiSa-2 preadipocytes.

Cite this paper

X. Huang and W. Dubiel, "The COP9 Signalosome Controls Adipocyte Differentiation by Regulating CHOP Protein Stability," Engineering, Vol. 4 No. 10B, 2012, pp. 192-193. doi: 10.4236/eng.2012.410B050.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Li, X. et al. (2006) Lactacystin inhibits 3T3-L1 adipocyte differentiation through induction of CHOP-10 expression. Biochem. Biophys. Res. Commun. 350, 1-6.
[2] Wei, N., Chamovitz, D.A. and Deng, X.W. (1994) Arabidopsis COP9 is a component of a novel signaling complex mediating light control of development. Cell 78, 117-124.
[3] Deshaies, R.J. and Joazeiro, C.A. (2009) RING domain E3 ubiquitin ligases. Annu. Rev. Biochem. 78, 399-434.
[4] Cope, G.A., Suh, G.S., Aravind, L., Schwarz, S.E., Zipursky, S.L., Koonin, E.V. and Deshaies, R.J. (2002) Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science 298, 608-611.
[5] Rogalla, S., Geier, C.F., Braumann, C., Ordemann, J., Müller, J.M. and Dubiel, W. (2010) in: 45th Congress of the European Society for Surgical Research - ESSR -, Vol. 45, pp. 17-23 (Cikirikcioglu, M., Ed.) MEDIMOND, Geneva, Switzerland.
[6] Braumann, C., Tangermann, J., Jacobi, C.A., Muller, J.M. and Dubiel, W. (2008) Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets. Mini Rev Med Chem 8, 421-428.
[7] Aggarwal, B.B. (2010) Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu. Rev. Nutr. 30, 173-199.

  
comments powered by Disqus

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.