Development of Hormone-Active Fiber in the Form of Artificial Insulin Depot

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DOI: 10.4236/eng.2012.410B049    2,040 Downloads   2,689 Views  

ABSTRACT

This study examines the phenomena of the hormone-active fibers obtaining process, in the form of artificial insulin depot. As a fibrous carrier of insulin cation-exchange polyacrylonitrile (PAN) fibers and biodegradable polysaccharide alginate fibers were used. The process of obtaining fibrous artificial insulin depot was based on the chemisorption of insulin from insulin aqueous solutions by these fibers. The parameters of insulin chemisorption reaction were determined and their influence on quantities of bonded insulin in the artificial depot was studied. The impact of fiber polymer nature on the intensity of insulin chemisorption was studied and determined. Also, the location and deposition of insulin in and onto the fiber, fiber topography were studied. The maximum amounts of bounded insulin for the cation-exchange PAN fibers were 395.0 mg porcine insulin chromatographic / g of fiber, and for the alginate fibers were about 300  mg of porcine insulin chromatographic / g of fiber.

Cite this paper

A. Medovic Baralic, P. Skundric, L. Sretkovic, I. Lijakovic and M. Kostic, "Development of Hormone-Active Fiber in the Form of Artificial Insulin Depot," Engineering, Vol. 4 No. 10B, 2012, pp. 189-191. doi: 10.4236/eng.2012.410B049.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] L. Brannon-Peppas, "Polymers in Controlled Drug Delivery, Medical Plastics and Biomaterials Magazine", November, 1997
[2] G. Coppi, V. Iannuccelli, E. Leo, M.T. Bernabei, R. Cameroni, "Protein immobilization in crosslinked alginate microparticles", Journal of Microencapsulation, Vol 19(1), pp. 37– 44, 2002
[3] R.S. Hermes, R. Narayani, "Polymeric alginate films and alginate beds for the controlled delivery of macromolecules", Trends. Biomater. Artif. Organs, Vol 5 (2) pp. 54-56, 2002.
[4] L.A. Wolf, Fibres of Specific Properties, Khimiya, Moscow, 1980, in Russian;
[5] P. Skundric, A. Medovic, M. Kostic, "Fibrous systems with programmed biological-activity and their application in medical practice", Autex Research Journal, Vol.2(2), pp.78-84, 2002?
[6] A. Medovic, "Study on phenomenon of fibres with programmed bioactivity production", Doctoral thesis, 2006, Faculty of Technology and metalurgy, University of Belgrade (in Serbian)?
[7] P. Skundric, M. Kostic, A. Medovic, LJ. Spasic-Kljajic, "The Mechanism and Kinetics of Obtaining the Biologically Active Complex Ffiber-Insulin as Artificial Insulin Store", 3rd AUTEX CONFERENCE, June 26-29, Gdansk, Poland, Book 1, pp. 44 – 50, 2003?
[8] A. Medovic, P. Skundric, M. Kostic, I. Pajic-Lijakovic ?Mathematical Modeling of Insulin Sorption by Ion-Exchange Fiber“, Journal of Applied Polymer Science, Volume 104, Issue 1, pp. 253-260, 2007,
[9] A. Medovic, P. Skundric, M. Kostic, I. Pajic-Lijakovic, ?The mathematical model of insulin desorption from the bioactive, fibrous artificial store“, Journal of Biomedical Materials Research Part A, Volume 79A, Issue 3, pp. 635 – 642, 2006
[10] J. Fabia, Cz. Slusarczyk, A. Gawlowski, Supermolecular Structure of Alginate Fibers, Fibers&Textile in Eastern Europe, Vol 13, No 5, pp.53, 2005

  
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