Dobesilate for dry age-related macular degeneration


We have evaluated the effects of intravitreal dobesilate, a synthetic fibroblast growth factor inhibitor, in patients with dry age-related macular degeneration, an inflammatory-related retinal disease without available treatment up to date. 36 eyes from 36 patients with dry age-related macular degeneration were treated with a single intravitreal dobesilate injection. The end points were the improvement from baseline visual acuity and normalization of retinal histology at one month. Intravitreal dobesilate injection resulted in a significant improvement in functional and anatomical outcomes at one month after injection. Our results suggest that intravitreal dobesilate may increase the chance of visual acuity gain in dry age-related macular degeneration, even in cases with initial low vision. This study supports the findings of previously published case reports, regarding the short-term improvement in visual acuity by intravitreal dobesilate injection in different degenerative retinal diseases.

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Cuevas, P. , Outeiriño, L. , Azanza, C. , Angulo, J. and Giménez-Gallego, G. (2013) Dobesilate for dry age-related macular degeneration. Journal of Biomedical Science and Engineering, 6, 8-14. doi: 10.4236/jbise.2013.610A2002.

Conflicts of Interest

The authors declare no conflicts of interest.


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