Analysis for stress environment in the alveolar sac model

Ramana M. Pidaparti; Matthew Burnette; Rebecca L. Heise; Angela Reynolds

doi:10.4236/jbise.2013.69110

Home > Journals > Biomedical & Life Sciences > JBiSE

JBiSE> Vol.6 No.9, September 2013

Share This Article:

Open Access

Analysis for stress environment in the alveolar sac model

Abstract Full-Text HTML

Download as PDF (Size:1384KB) PP. 901-907

DOI: 10.4236/jbise.2013.69110 4,405 Downloads 5,783 Views Citations

Author(s) Leave a comment

Ramana M. Pidaparti, Matthew Burnette, Rebecca L. Heise, Angela Reynolds

Affiliation(s)

Department of Applied Mathematics Virginia Commonwealth University, Richmond, USA.
Department of Biomedical Engineering Virginia Commonwealth University, Richmond, USA.
Department of Mechanical and Nuclear Engineering Virginia Commonwealth University, Richmond, USA.

ABSTRACT

Better understanding of alveolar mechanics is very important in order to avoid lung injuries for patients undergoing mechanical ventilation for treatment of respiratory problems. The objective of this study was to investigate the alveolar mechanics for two different alveolar sac models, one based on actual geometry and the other an idealized spherical geometry using coupled fluid-solid computational analysis. Both the models were analyzed through coupled fluid-solid analysis to estimate the parameters such as pressures/ velocities and displacements/stresses under mechanical ventilation conditions. The results obtained from the fluid analysis indicate that both the alveolar geometries give similar results for pressures and velocities. However, the results obtained from coupled fluid-solid analysis indicate that the actual alveolar geometry results in smaller displacements in comparison to a spherical alveolar model. This trend is also true for stress/strain between the two models. The results presented indicate that alveolar geometry greatly affects the pressure/velocities as well as displacements and stresses/strains.

KEYWORDS

Alveolar Sac; Stress; Analysis; Modeling

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Pidaparti, R. , Burnette, M. , Heise, R. and Reynolds, A. (2013) Analysis for stress environment in the alveolar sac model. Journal of Biomedical Science and Engineering, 6, 901-907. doi: 10.4236/jbise.2013.69110.

References

[1]	Koombua, K., Pidaparti, R.M., Longest, P.W. and Ward, K.R. (2009) Biomechanical aspects of compliant airways due to mechanical ventilation. Tech Sciences Press, 151, 1-19.

[2]	Pidaparti, R.M., Koombua, K. and Ward, K.R. (2011) Assessment of mechanical ventilation parameters on respiratory mechanics. Journal of Medical Engineering & Technology, 36, 34-41.

[3]	Gehr, P., Bachofen, M. and Weibel, E.R. (1978) The normal human lung: Ultrastructure and morphometric estimation of diffusion capacity. Respiration Physiology, 32, 121-140. doi:10.1016/0034-5687(78)90104-4

[4]	Harwood, J.L. and Richards, R.J. (1985) Lung surfactant. Molecular Aspects of Medicine, 8, 423-514. doi:10.1016/0098-2997(85)90012-3

[5]	Abraham, T. and Hogg, J. (2010) Extracellular matrix remodeling of lung alveolar walls in three-dimensional space identified using second harmonic generation and multiphoton excitation fluorescence. Journal of Structural Biology, 171, 189-196. doi:10.1016/j.jsb.2010.04.006

[6]	Pena, A.M., Fabre, A., Débarre, D., Marchal-Somme, J., Crestani, B., Martin, J.L., Beaurepaire, E. and Schanne-Klein, M.C. (2007) Three-dimensional investigation and scoring of extracellular matrix remodeling during lung fibrosis using multiphoton microscopy. Microscopy Research and Technique, 70, 162-170. doi:10.1002/jemt.20400

[7]	Gefen, A., Elad, D. and Shiner, R.J. (1999) Analysis of stress distribution in the alveolar septa of normal and simulated emphysematic lungs. Journal of Biomechanics, 32, 891-897. doi:10.1016/S0021-9290(99)00092-5

[8]	Suki, B., Ito, S., Stamenovic, D., Lutchen, K.R. and Ingenito, E.P. (2005) Biomechanics of the lung parenchyma: Critical roles of collagen and mechanical forces. Journal of Applied Physiology, 98, 1892-1899. doi:10.1152/japplphysiol.01087.2004

[9]	Stamenovic, D. (2005) Effects of cytoskeletal prestress on cell rheological behavior. Acta Biomaterilia, 1, 255-262.

[10]	Suki, B. and Bates, J.H.T. (2008) Extracellular matrix mechanics in lung parenchymal diseases. Respiratory Physiology & Neurobiology, 163, 33-43. doi:10.1016/j.resp.2008.03.015

[11]	Denny, E. and Schroter, R.C. (2006) A model of non-uniform lung parenchyma distortion. Journal of Biomechanics, 39, 652-663. doi:10.1016/j.jbiomech.2005.01.010

[12]	Li, Z. and Kleinstreuer, C. (2011) Airflow analysis in the alveolar region using the lattice-Boltzmann method. Medical & Biological Engineering & Computing, 49, 441-451. doi:10.1007/s11517-011-0743-1

[13]	Dailey, H.L. and Ghadiali, S.N. (2007) Fluid-structure analysis of microparticle transport in deformable pulmonary alveoli. Journal of Aerosol Science, 38, 269-288. doi:10.1016/j.jaerosci.2007.01.001

[14]	Rausch, S.M.K., Martin, C., Bornemann, P.B., Uhlig, S. and Wall, W.A. (2011) Material model of lung parenchyma based on living precision-cut lung slice testing. Journal of the Mechanical Behavior of Biomedical Materials, 4, 583-592. doi:10.1016/j.jmbbm.2011.01.006

[15]	Bachofen, H. and Schürch, S. (2001) Alveolar surface forces and lung architecture. Comparative Biochemistry and Physiology Part A, 129, 183-193.