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6-Azido-Galactosyl Imidate as a Building Block for Preparation of 1-(4-Aminobutyl)-, Di-, Tri- and Tetra-Saccharides

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DOI: 10.4236/ojmc.2013.33010    4,200 Downloads   6,575 Views   Citations


6-azidogalactosyl imidate has been used as a donor to generate 1-(4-aminobutyl)-6-aminogalactose, 6-aminothiotolyl- glycosides of disaccharide, trisaccharide and tetrasaccharide that incorporates 6-azido group and 1-(4-tolyl)thio group. Trisaccharide and tetrasaccharide were obtained from lactosyl-based acceptor. The anomeric 1-(4-tolyl)thio group could be used to conjugate with sphingosine analogs to provide the alpha-Gal Sph analogs for library extension from the azido group.

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K. Lin, L. Chiang, C. Pan, H. Huang, Y. Su, S. Chen, Y. Huang and C. Yu, "6-Azido-Galactosyl Imidate as a Building Block for Preparation of 1-(4-Aminobutyl)-, Di-, Tri- and Tetra-Saccharides," Open Journal of Medicinal Chemistry, Vol. 3 No. 3, 2013, pp. 74-86. doi: 10.4236/ojmc.2013.33010.


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