Ubiquitin-conjugating enzyme involved in the immune response caused by pathogens invasion


Ubiquitin-proteasome pathway (UPP) is a significant way of protein degradation and modification in eukaryotic cell and involved in a complex series of intracellular processes. As a key component in UPP, ubiquitin-conjugating enzyme (E2) plays an extremely important role in ubiquitin (Ub) transferring and substrate specific recognition. Abundant evidences have proved that UPP is involved in cells immune reaction caused by pathogens and the attendance of E2 has a significant effect on host cells and pathogen. This article presents an overview of the current research on E2s that is involved in immune response caused by viruses and bacteria.

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Chen, L. , Cheng, C. , Zhang, C. , Yao, Q. and Zhao, E. (2013) Ubiquitin-conjugating enzyme involved in the immune response caused by pathogens invasion. Open Journal of Immunology, 3, 93-97. doi: 10.4236/oji.2013.33013.

Conflicts of Interest

The authors declare no conflicts of interest.


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