Share This Article:

Quality of Life in Egyptian Children with Cancer

Abstract Full-Text HTML Download Download as PDF (Size:213KB) PP. 1256-1261
DOI: 10.4236/jct.2013.47148    3,757 Downloads   5,726 Views   Citations

ABSTRACT

Background and Objectives: Cancer treatments leading to increased survival rates are reported to participate in the creation of debilitating physical and psychosocial deficits for cancer survivors. Measures of health-related quality of life (HRQOL) are designed to tap such consequences of cancer treatment together with the impact of the disease itself. Methods: Parents of 67 included patients aged 8 - 12 years, were asked to complete the parent proxy report of PedsQLTM 3.0 Cancer Module (Arabic version), as well as a separate sheet for socio-demographic data. Results: The ratio of Males to females was 1.8:1 among study patients with a median age of 8 years at diagnosis. Hematological malignancies represented 70.1% of the sample, with the highest proportion for ALL (52.2%). Total QOL showed to be relatively low with mean value of 62.29 for the whole group. Subscales with least scores were for; worry (44.11), perceived physical appearance (50.6), and procedural anxiety (55.34). On the other hand, the best score was 75.98 for communication, followed by 72.63 for cognitive problems. The impacts of some medical and socio-demographic variables on QOL and its subscales were elicited in our results. Conclusion: Increased treatment intensity, long duration of hospital admission, higher frequency of hospital visits, female sex, younger age at diagnosis, and large family size were all associated with a poorer total QOL and/or its subscales among Egyptian pediatric cancer patients.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

M. Fawzy, M. Saleh, M. El-Wakil, Z. Monir and E. Eltahlawy, "Quality of Life in Egyptian Children with Cancer," Journal of Cancer Therapy, Vol. 4 No. 7, 2013, pp. 1256-1261. doi: 10.4236/jct.2013.47148.

References

[1] G. W. Chang, A. Shad, S. N. Myers and K. Hennessy, “Late Effects in Cancer Survivors: The Shared Care Model,” Current Oncology Reports, Vol. 14, No. 2, 2012, pp. 182-190. doi:10.1007/s11912-012-0224-1
[2] C. Eiser and R. Morse, “A Review of Measures of Quality of Life for Children with Chronic Illness,” Archives of Disease in Childhood, Vol. 84, 2001, pp. 205-211. doi:10.1136/adc.84.3.205
[3] J. W. Varni, T. M. Burwinkle, E. R. Katz, K. Meeske and P. Dickinson, “The PedsQL in Pediatric Cancer: Reliability and Validity of the Pediatric Quality of Life Inventory Generic Core Scales, Multidimensional Fatigue Scale, and Cancer Module,” Cancer, Vol. 94, No. 7, 2002, pp. 2090-2106. doi:10.1002/ cncr.10428
[4] M. F. Lorenzi, L. Xie, P. C. Rogers, S. Pritchard, K. Goddard and M. L. McBride, “Hospital-Related Morbidity among Childhood Cancer Survivors in British Columbia, Canada: Report of the Childhood, Adolescent, Young Adult Cancer Survivors (CAYACS) Program,” International Journal of Cancer, Vol. 128, No. 7, 2011, pp. 1624-1631. doi:10.1002/ijc.25751
[5] M. M. Geenen, M. C. Cardous-Ubbink, C. van den Bos, H. J. van der Pal, R. C. Heinen, M. W. Jaspers, C. C. Koning, F. Oldenburger, N. E. Langeveld, A. A. Hart, P. J. Bakker, H. N. Caron and F. E. van Leeuwen, “Medical Assessment of Adverse Health Outcomes in Long-Term Survivors of Childhood Cancer,” Journal of the American Medical Association, Vol. 297, No. 24, 2007, pp. 2705-2715. doi:10.1001/jama.297.24.2705
[6] B. A. Kurt, V. G. Nolan, K. K. Ness, J. P. Neglia, J. M. Tersak, M. M. Hudson, G. T. Armstrong, R. J. Hutchinson, W. M. Leisenring, K. C. Oeffinger, L. L. Robison and M. Arora, “Hospitalization Rates among Survivors of Childhood Cancer in the Childhood Cancer Survivor Study Cohort,” Pediatric Blood & Cancer, Vol. 59, No. 1, 2012, pp. 126-132. doi:10.1002/pbc.24017
[7] J. W. Varni, M. Seid and C. A. Rode, “PedQLTM 4.0: Measurement Model for the Pediatric Quality of Life InventoryTM,” Medical Care, Vol. 37, 1999, pp. 126-139. doi:10.1097/00005650-199902000-00003
[8] N. Yaris, M. Yavuz, A. Yavuz and A. Okten, “Assessment of Quality of Life in Pediatric Cancer Patients at Diagnosis and During Therapy,” Turkish Journal of Cancer, Vol. 31, No. 4, 2001, pp. 139-149.
[9] L. Sung, R. J. Klaassen, D. Dix, S. Pritchard, R. Yanofsky, B. Dzolganovski, R. Almeida and A. Klassen, “Identification of Paediatric Cancer Patients with Poor Quality of Life,” British Journal of Cancer, Vol. 100, No. 1, 2009, pp. 82-88. doi:10.1038/sj.bjc.6604826
[10] Z. Chaudhry and S. Siddiqui, “Health Related Quality of Life Assessment in Pakistani Paediatric Cancer Patients Using PedsQLTM 4.0 Generic Core Scale and PedsQL? Cancer Module,” Health and Quality of Life Outcomes, Vol. 10, 2012, p. 52. doi:10.1186/1477-7525-10-52
[11] L. Fallowfield, “Quality of Life: A New Perspective for Cancer Patients,” Nature Reviews Cancer, Vol. 2, 2002, pp. 873-879. doi:10.1038/nrc930
[12] J. W. Varni, T. M. Burwinkle, M. Seid and D. Skarr, “The PedsQL? 4.0 as a Pediatric Population Health Measure: Feasibility, Reliability, and Validity,” Ambulatory Pediatrics, Vol. 3, No. 6, 2003, pp. 329-341. doi:10.1367/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2
[13] M. Sprangers, A. Cull, M. Groenvold, K. Bjordal, J. Blazeby and N. K. Aaronson, “The European Organization for Research and Treatment of Cancer approach to Developing Questionnaire Modules: An Update and Overview,” Quality of Life Research, Vol. 7, 1998, pp. 291-300. doi:10.1023/ A:1008890401133
[14] O. Magal-Vardi, N. Laor, A. Toren, L. Strauss, L. Wolmer, B. Bielorai, G. Rechavi and P. Toren, “Psychiatric Morbidity and Quality of Life in Children with Malignancies and Their Parents,” The Journal of Nervous and Mental Disease, Vol. 92, 2004, pp. 872-875. doi:10.1097/ 01.nmd. 0000146881.00129.ec
[15] M. A. Landolt, M. Vollrath, F. K. Niggli, H. E. Gnehm and F. H. Sennhauser, “Health-Related Quality of Life in Children with Newly Diagnosed Cancer: A One Year Follow-Up Study,” Health and Quality of Life Outcomes, Vol. 4, 2006, p. 63. doi:10.1186/1477-7525-4-63
[16] P. M. Ho, C. L. Bryson and J. S. Rumsfeld, “Medication Adherence: Its Importance in Cardiovascular Outcomes,” Circulation, Vol. 119, No. 23, 2009, pp. 3028-3035. doi:10.1161/ CIRCULATIONAHA. 108.768986
[17] M. N. Sitaresmi, S. Mostert, C. M. Gundy, Sutaryo and A. J. P. Veerman, “Health-Related Quality of Life Assessment in Indonesian Childhood Acute Lymphoblastic Leukemia,” Health and Quality of Life Outcomes, Vol. 6, No. 1, 2008, p. 96. doi:10.1186/1477-7525-6-96
[18] Y. Ji, S. Chen and K. Li, “Measuring Health-Related Quality of Life in Children with Cancer Living in Mainland China: Feasibility, Reliability and Validity of the Chinese Mandarin Version of PedsQL 4.0 Generic Core Scales and 3.0 Cancer Module,” Health and Quality of Life Outcomes, Vol. 9, 2011, p. 103 doi:10.1186/1477-7525-9-103
[19] C. R. Baggott, M. Dodd, C. Kennedy, N. Marina, K. K. Matthay, B. Cooper and C. Miaskowski, “An Evaluation of the Factors that Affect the Health-Related Quality of Life of Children Following Myelosuppressive Chemotherapy,” Supportive Care in Cancer, Vol. 19, No. 3, 2011, pp. 353-361. doi:10.1007/s00520-010-0824-y
[20] E. Grevelman and W. P. Breed, “Prevention of Chemotherapy-Induced Hair Loss by Scalp Cooling,” Annals of Oncology, Vol. 16, No. 3, 2005, pp. 352-358. doi:10.1093/annonc/mdi088
[21] K. Lotfi-Jam, M. Carey, M. Jefford, P. Schofield, C. Charleson and S. Aranda, “Nonpharmacologic Strategies for Managing Common Chemotherapy Adverse Effects: A Systematic Review,” Journal of Clinical Oncology, Vol. 26, No. 34, 2008, pp. 5618-5629. doi:10.1200/JCO.2007.15.9053
[22] M. W. Bishop, “Therapy-Related Events and HealthRelated Quality of Life for Children with Leukemia and Lymphoma,” 2012. http://etd.ohiolink.edu/view.cgi?acc_num=ucin1342544150
[23] S. A. Payne, “A Study of Quality of Life in Cancer Patients Receiving Palliative Chemotherapy,” Social Science & Medicine, Vol. 35, No. 12, 1992, pp. 1505-1509. doi:10.1016/0277-9536(92)90053-S
[24] J. M. Borras, A. Sanchez-Hernandez, M. Navarro, M. Martinez, E. Mendez, J. L. L. Ponton, J. A. Espinas and J. R. Germa, “Compliance, Satisfaction, and Quality of Life of Patients with Colorectal Cancer Receiving Home Chemotherapy or Outpatient Treatment: A Randomised Controlled Trial,” British Medical Journal, Vol. 322, 2001, pp. 1-5. doi:10.1136/bmj.322.7290.826
[25] J. L. Richardson, G. Marks and A. Levine, “The Influence of Symptoms of Disease and Side Effects of Treatment on Compliance with Cancer Therapy,” Journal of Clinical Oncology, Vol. 6, No. 11, 1988, pp. 1746-1752.
[26] C. Eiser and R. Eiser, “Mothers’ Ratings of Quality of Life in Childhood Cancer: Initial Optimism Predicts Improvement over Time,” Psychology & Health, Vol. 22, No. 5, 2007, pp. 535-543. doi:10.1080/14768320701202074
[27] K. N. Speechley, M. Barrera, A. K. Shaw, H. I. Morrison and E. Maunsell, “Health Related Quality of Life among Child and Adolescent Survivors of Childhood Cancer,” Journal of Clinical Oncology, Vol. 24, No. 16, 2006, pp. 2536-2543. doi:10.1200/JCO.2005.03.9628
[28] K. A. Moore, S. Vandivere and Z. Redd, “A Sociodemographic Risk Index,” Social Indicators Research, Vol. 75, No. 1, 2006, pp. 45-81. doi:10.1007/s11205-004-6398-7
[29] L. P. Barakat, P. L. Marmer and L. A. Schwartz, “Quality of Life of Adolescents with Cancer: Family Risks and Resources,” Health and Quality of Life Outcomes, Vol. 8, 2010, p. 63. doi:10.1186/1477-7525-8-63
[30] K. A. Meeske, S. K. Patel and S. N. Palmer, “Factors Associated with Health-Related Quality of Life in Pediatric Cancer Survivors. Factors Associated with HealthRelated Quality of Life in Pediatric Cancer Survivors,” Pediatric Blood and Cancer, Vol. 49, 2007. pp. 298-305. doi:10.1002/pbc.20923
[31] M. A. Cantrell, “Health-Related Quality of Life in Childhood Cancer: State of the Science,” Oncology Nursing Forum, Vol. 34, No. 1, 2007, pp. 103-111. doi:10.1188/07.ONF.103-111
[32] I. Sabbah, H. Sabbah, S. Sabbah, H. Akoum, N. Droubi and M. Mercier, “Measurement Properties of the Arabic Lebanon Version of the Pediatric Quality of Life Inventory 4.0 Generic Core Scales for Young Child (5-7 Years), and Child Aged 8-12 Years: Quality of Life in Urban and Rural Children in Lebanon,” Creative Education, Vol. 3, 2012, pp. 959-970.

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.