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Bilateral nephromegaly and arthritis: A rare presentation of acute lymphoblastic leukemia

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DOI: 10.4236/ojped.2013.33044    3,763 Downloads   5,520 Views   Citations

ABSTRACT

A 2.5 years old boy presented with fever, intermittent small joint arthritis of hands and feet, bilateral nephromegaly with normal hemogram and uric acid level. Bone marrow aspiration revealed pre-B acute lymphoblastic leukemia without leukemic infiltration of kidneys. Leukemia should be suspected in any patient with arthritis and nephromegaly.

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Sabui, T. , Sardar, S. , Laha, S. and Roy, A. (2013) Bilateral nephromegaly and arthritis: A rare presentation of acute lymphoblastic leukemia. Open Journal of Pediatrics, 3, 257-259. doi: 10.4236/ojped.2013.33044.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Schrappe, M., Reiter, A., Ludwig, W.D., et al. (2000) Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: Results of trial ALL-BFM 90. Blood, 95, 3310-3322.
[2] Boueva, A. and Bouvier, R. (2005) B-cell lympholblastic leukemia as a cause of bilateral nephromegaly. Pediatric Nephrology, 20, 679-682. doi:10.1007/s00467-004-1740-5
[3] Basker, M., Scott, J.X., Ross, B., et al. (2002) Renal enlargement as primary presentation of acute lymphoblastic leukemia. Indian Journal of Cancer, 39, 154-156.
[4] Rudramurthy, P., Madhumathi, S.D., et al. (2008) Bilateral nephromegaly simulating wilms tumour: A rare initial manifestation of acute lymphoblastic leukemia. Journal of Pediatric Hematology/Oncology, 30, 471-473. doi:10.1097/MPH.0b013e318168e7b3
[5] Ali, S.H., Yacoub, F.M. and Al Matar, E. (2008) Acute lymphoblastic leukemia presenting as bilateral renal enlargement in a child. Medical Principles and Practice, 17, 504-506. doi:10.1159/000151576
[6] Frei III, E., Fritz, R.D., Price, E., et al. (1963) Renal and hepatic enlargement in acute leukemia. Cancer,16,1089-1092. doi:10. 1002/1097-0142(1963 08)16:8<1089:: AID-CNCR2820160817>3.0. CO;2-1
[7] Glicklich, D., Sung, M.V. and Frey, M. (1986) Renal failure due to lymphomatous infiltration of the kidneys.Cancer,58,748-753. doi:10.1002/1097-0142(19860801)58:3<748::AID-CNCR28205 80323 >3.0.CO; 2-U
[8] Trapani, S., Grisolia, F., Simonini, G., et al. (2000) Incidence of occult cancer in children presenting with musculoskeletal symptoms: A 10 yr survey in pediatric rheumatology unit. Semin Arthritis Rheum, 29, 348-359. doi:10.1053/sarh.2000.5752
[9] Marwaha, R.K., Kulkarni, K.P., Bansal, D. and Trehan, A. (2010) Acute lymphoblastic leukemia masquerading as juvenile rheumatoid arthritis: Diagnostic pitfall and association with survival. Annals of Hematology, 89, 249-254. doi:10.1007/s00277-009-0826-3
[10] Jung, A. and Nielsen, S.M. (1998) Arthritis as first symptom of leukemia in children. Ugeskrift for Laeger, 160, 2889-2890.
[11] Robazzi, T.C., Barreto, J.H., Silva, L.R., et al. (2007) Osteoarticular manifestations as initial presentation of acute leukemias in children and adolescents in Bahia, Brazil. Journal of Pediatric Hematology/Oncology, 29, 622-626.

  
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