Evaluation of CDK6 and p16/INK4a-Derived Peptides Interaction


 The goal of this work is the development of novel peptides with high efficacy of inhibiting activity of CDK6/CyclinD complex. The peptides were derived from primary sequence of P16 protein and its homologues. The interactions between CDK6 and P16/INK4a-derived peptides are studied with molecular dynamics simulation employing umbrella sampling method. The SASA implicit solvent model was used for simulation, which was accelerated using NVIDIA GPUs.

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Kazennov, A. , Alekseenko, A. , Bozhenko, V. , Kulinich, T. , Shuvalov, N. and Kholodov, Y. (2013) Evaluation of CDK6 and p16/INK4a-Derived Peptides Interaction. Computational Molecular Bioscience, 3, 53-57. doi: 10.4236/cmb.2013.33007.

Conflicts of Interest

The authors declare no conflicts of interest.


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