Management of the Case of a Young Female Patient with Multiple Malignancies and Germline R24P CDKN2A Gene Mutation

Gabriella Uhercsák, Ágnes Dobi, Roland Gyulai, Judit Oláh, László Kaizer, Katalin Ormándi, Adrienne Cserháti, György Lázár, Gyula Farkas, Zsuzsanna Kahán

Department of Dermatology and Immunology, University of Szeged, Szeged, Hungary.
Department of Oncotherapy, University of Szeged, Szeged, Hungary.
Department of Oncotherapy, University of Szeged, Szeged, Hungary; 2Department of Dermatology and Immunology, University of Szeged, Szeged, Hungary.
Department of Pathology, University of Szeged, Szeged, Hungary.
Department of Radiology, University of Szeged, Szeged, Hungary.
Department of Surgery, University of Szeged, Szeged, Hungary.

DOI: 10.4236/jct.2013.47A004                

Abstract

The case of a young female patient with metachronous primary melanomas, advanced breast and pancreatic cancers is reported. The 5 different tumors diagnosed within six years, were managed with curative intent. Genetic analysis revealed the mutation of the R24P CDKN2A gene in a heterozygote form in both the patient and her father. Careful tertiary prevention during the follow-up of the patient is needed.

Keywords

Breast Cancer; Melanoma; Pancreatic Cancer; R24P CDKN2A Gene Mutation

Conflicts of Interest

The authors declare no conflicts of interest.

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