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Synthesis and bioevaluation of novel heterostilbenes as potential anti-inflammatory and anti-angiogenic agents

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DOI: 10.4236/mri.2013.23005    2,965 Downloads   6,199 Views   Citations

ABSTRACT

Novel heterocyclic analogs of resveratrol, (E)-stilbene analogs, were readily prepared by conjugation of a heterocyclic benzothiazolium moiety with the core styrene structure of resveratrol and evaluated for their biological properties. The results showed that these analogs were superior to resveratrol in 1) anti-angiogenesis in vitro, 2) nitric oxide inhibition in vitro, and 3) inhibition of carrageenan-induced edema in vivo. In summary, introduction of a heterocyclic benzothiazolium moiety to replace one of two aromatic rings from the core stilbene structure of resveratrol provided beneficial biological properties and is worthy of further investigation.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Huang, C. , Lee, A. , Shaw, J. and Huang, W. (2013) Synthesis and bioevaluation of novel heterostilbenes as potential anti-inflammatory and anti-angiogenic agents. Modern Research in Inflammation, 2, 37-45. doi: 10.4236/mri.2013.23005.

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