Thermal Decomposition of Some Cardiovascular Drugs (Telmisartane, Cilazapril and Terazosin HCL)

Abstract

Thermal analysis of some antihypertensive drugs, Telmisartan, Cilazapril and Terazosin HCL was achieved. Thermogravimetry, derivative thermogravimetry and differential thermal analysis were used through the work. Thermogravimetric parameters such as activation energy, frequency factor and reaction order were calculated. The results show the stability value decrease in the order Telmisartan > Cilazapril > Terazosin. This method can be used in the quality control of pharmaceutical compounds because it is simple, fast and cheap.

Share and Cite:

L. Al-Harbi, E. El-Mossalamy, A. Obaid and M. EL-RIES, "Thermal Decomposition of Some Cardiovascular Drugs (Telmisartane, Cilazapril and Terazosin HCL)," American Journal of Analytical Chemistry, Vol. 4 No. 7, 2013, pp. 337-342. doi: 10.4236/ajac.2013.47042.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] D. Giron, “Pharmaceutical Science and Technology Today (PSTT),” 1998.
[2] Y. I. Huang, Y. H. Cheng, K. S. Alexander and D. Dollimore, “The Thermal Analysis of the Drug Captopril,” Proceedings of the 27th Conference of the North American Thermal Analysis Society, 1999, p. 612.
[3] J. L. Ford and P. Timmings, “Pharmaceutical Thermal Analysis Techniques and Applications,” Ellis Harwood, Chichistero, 1989.
[4] R. F. Bruns, “Effects of Experimental Conditions on the Estimation of Kinetic Parameters of the Thermal Decomposition of AZT Using Factorial Design,” Journal of Thermal Analysis and Calorimetry, Vol. 79, No. 3, 2005, pp. 697-701. doi:10.1007/s10973-005-0598-5
[5] A. P. Barre, L. O. Gomes, F. S. Souza and R. O. Macedo, “Application of Thermal Analysis in the Characterization of Antihypertensive Drugs,” Journal of Thermal Analysis and Calorimetry, Vol. 64, 2001, pp. 745-650.
[6] L. Burham, D. Dollimore and K. S. Alekender, L. K. Burhnam, D. Dollimore and K. S. Alexander, “A Rising Temperature Kinetic Model to Describe Complex Reaction Kinetics of a Drug: Procainamide Hydrochloride,” Proceedings of the 26th Conference of the North American Thermal Analysis Society, 1998, p. 294.
[7] L. Burnham, D. Dollimore and K. S. Alexander, “Calculation of the Vapor Pressure-Temperature Relationship Using Thermogravimetry for the Drug Allopurinol,” Proceedings of the 27th Conference of the North American Thermal Analysis Society, 1999, p. 602.
[8] R. O. Macedo, T. Gomes do Nascimento, C. F. Soares Aragao and A. P. Barreto Games, “Application of Thermal Analysis in The Characterization of Anti-hypertensive Drugs,” Journal of Thermal Analysis and Calorimetry, Vol. 59, 2000, pp. 657-661.
[9] “Merck Index,” 14th Edition, 2006, p. 9131.
[10] “Merck Index,” 14th Edition, 2006, p. 2270.
[11] P. Holm and A. Kristensen, “A Method for Drug Formulation and a Pharmaceutical Composition,” 1992.
[12] H. H. Horowitz and G. Metzger, “A New Analysis of Thermogravimetric Traces,” Analytical Chemistry, Vol. 35, No. 10, 1963, pp. 1464-1468. doi:10.1021/ac60203a013
[13] A. W. Coats and J. P. Redfern, “Kinetic Parameters from Thermogravimetric Data,” Nature, Vol. 201, 1964, pp. 68-69.

Copyright © 2022 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.