Risk Assessment for Metals and PAHs by Mediterranean Seafood


Fish is a very important food because of its high nutritional value. Fish consumption is largely recommended in all countries, so quality and safety of seafood are becoming of great concern. Especially in Mediterranean Sea, where many pollutants, as metals and Polycyclic Aromatic Hydrocarbons (PAHs), are often relieved also in high concentrations, seafood safety has to be checked by a methodologically rigorous risk assessment. So we propose in this paper a stagesrisk assessment methodology to estimate the seafood potential risk for human health and point-out critical topics in order to support fish advisories.

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C. Copat, G. Conti, C. Signorelli, S. Marmiroli, S. Sciacca, M. Vinceti and M. Ferrante, "Risk Assessment for Metals and PAHs by Mediterranean Seafood," Food and Nutrition Sciences, Vol. 4 No. 7A, 2013, pp. 10-13. doi: 10.4236/fns.2013.47A002.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] E. I. Adeyeye, “Determination of the Chemical Composition of the Nutritionally Valuable Parts of Male and Female Common West African Fresh Water Crab Sudananautes africanus africanus,” International Journal of Food Sciences and Nutrition, Vol. 53, No. 3, 2002, pp. 189-196. doi:10.1080/09637480220132805
[2] P. A. Zalloua, Y. H. Hsu, H. Terwedow, T. Zang, D. Wu, G. Tang, Z. Li, X. Hong, S. T. Azar, B. Wang, M. L. Bouxsein, J. Brain, S. R. Cummings, C. J. Rosen and X. Xu, “Impact of Seafood and Fruit Consumption on Bone Mineral Density,” Maturitas, Vol. 56, No. 1, 2007, pp. 1-11. doi:10.1016/j.maturitas.2006.05.001
[3] B. Ersoy and M. Celik, “The Essential and Toxic Elements in Tissues of Six Commercial Demersal Fish from Eastern Mediterranean Sea,” Food and Chemical Toxicology, Vol. 48, No. 5, 2010, pp. 1377-1382. doi:10.1016/j.fct.2010.03.004
[4] B. Olang, M. Hajifaraji, M. A. Ali, S. Hellstrand, M. Palesh, E. Azadnyia, Z. Kamali, B. Strandvik and A. Yngve, “Docosahexaenoic Acid in Breast Milk Reflects Maternal Fish Intake in Iranian Mothers,” Food and Nutrition Sciences, Vol. 3, No. 4, 2012, pp. 441-446.
[5] E. P. Neale, A. Cossey, Y. C. Probst, M. J. Batterham and L. C. Tapsell, “Effectiveness of Dietary Advice to Increase Fish Consumption over a 12-Month Period,” Food and Nutrition Sciences, Vol. 3, No. 4, 2012, pp. 455-460. doi:10.4236/fns.2012.34065
[6] J. L. Domingo, A. Bocio, G. Falco and J. M. Llobet, “Benefits and Risks of Fish Consumption Part I. A Quantitative Analysis of the Intake of Omega-3 Fatty Acids and Chemical Contaminants,” Toxicol, Vol. 230, No. 2-3, 2007, pp. 219-226. doi:10.1016/j.tox.2006.11.054
[7] G. Longo, M. Trovato, V. Mazzei, M. Ferrante and G. Oliveri Conti, “Ligia italica (Isopoda, Oniscidea) as Bioindicator of Mercury Pollution of Marine Rocky Coasts,” PLoS One, Vol. 8, No. 3, 2013, Article ID: e58548. doi:10.1371/journal.pone.0058548
[8] G. O. Conti, C. Copat, C. Ledda, M. Fiore, R. Fallico, S. Sciacca and M. Ferrante, “Evaluation of Heavy Metals and Polycyclic Aromatic Hydrocarbons (PAHs) in Mullus barbatus from Sicily Channel and Risk-Based Consumption Limits,” Bulletin of Environmental Contamination and Toxicology, Vol. 88, No. 6, 2012, pp. 946-950. doi:10.1007/s00128-012-0611-1
[9] C. Copat, F. Bella, M. Castaing, R. Fallico, S. Sciacca and M. Ferrante, “Heavy Metals Concentrations in Fish from Sicily (Mediterranean Sea) and Evaluation of Possible Health Risks to Consumers,” Bulletin of Environmental Contamination and Toxicology, Vol. 88, No. 1, 2012, pp. 78-83. doi:10.1007/s00128-011-0433-6
[10] C. Copat, M. V. Brundo, G. Arena, A. Grasso, G. Oliveri Conti, C. Ledda, R. Fallico, S. Sciacca and M. Ferrante, “Seasonal Variation of Bioaccumulation in Engraulis encrasicolus (Linneaus, 1758) and Related Biomarkers of Exposure,” Ecotoxicology and Environmental Safety, Vol. 86, 2012, pp. 31-37. doi:10.1016/j.ecoenv.2012.09.006
[11] B. Tomasello, C. Copat, V. Pulvirenti, V. Ferrito, M. Ferrante, M. Renis, S. Sciacca and C. Tigano, “Biochemical and Bioaccumulation Approaches for Investigating Marine Pollution Using Mediterranean Rainbow Wrasse, Coris julis (Linneaus 1798),” Ecotoxicology and Environmental Safety, Vol. 86, 2012, pp. 168-175. doi:10.1016/j.ecoenv.2012.09.012
[12] C. Copat, R. Maggiore, G. Arena, S. Lanzafame, R. Fallico, S. Sciacca and M. Ferrante, “Evaluation of a Temporal Trend Heavy Metals Contamination in Posidonia oceanica (L.) Delile, (1813) along the Western Coastline of Sicily (Italy),” Journal of Environmental Monitoring, Vol. 14, No. 1, 2012, pp. 187-192. doi:10.1039/c1em10575b
[13] US-EPA, “Guidance for Assessing Chemical Contamination Data for Use in Fish Advisories Volume II. Risk Assessment and Fish Consumption Limits EPA/823-B94004,” United States Environmental Protection Agency, Washington DC, 2000. http://www.epa.gov/spc/pdfs/rchandbk.pdf
[14] R. Ferrara, B. Mazzolai, E. Lanzillotta, E. Nucaro and N. Pirrone, “Volcanoes as Emission Sources of Atmospheric Mercury in the Mediterranean Basin,” Science of the Total Environment, Vol. 259, No. 1-3, 2000, pp. 115-121. doi:10.1016/S0048-9697(00)00558-1
[15] R. Di Leonardo, G. Tranchida, A. Bellanca, R. Neri, M. Angelone and S. Mazzola, “Mercury Levels in Sediments of Central Mediterranean Sea: A 150+ Year Record from Box-Cores Recovered in the Strait of Sicily,” Chemosphere, Vol. 65, No. 11, 2006, pp. 2366-2376. doi:10.1016/j.chemosphere.2006.04.076
[16] US-EPA, “Risk Assessment Guidance for Superfund Volume I. Human Health Evaluation Manual (Part A)”, Interim Final. EPA 540/1-89/002,” United States Environmental Protection Agency, Washington DC, 1989. http://www.epa.gov/spc/pdfs/rchandbk.pdf
[17] UNEP, “Mediterranean Regional Report. Regionally Based Assessment of Persistent Toxic Substances,” 1996. http://www.chem.unep.ch/
[18] US-EPA, “Exposure Factors Handbook,” National Center for Environmental Assessment, Washington DC, 1997. http://www.epa.gov/spc/pdfs/rchandbk.pdf
[19] US-EPA, “Risk-Based Concentration Table,” United States Environmental Protection Agency, Philadelphia, 2000. http://www.epa.gov/spc/pdfs/rchandbk.pdf
[20] I. Mansilla-Rivera and C. J. Rodriguez-Sierra, “Metal Levels in Fish Captured in Puerto Rico and Estimation of Risk from Fish Consumption,” Archives of Environmental Contamination and Toxicology, Vol. 60, No. 1, 2011, pp. 132-144.
[21] US-EPA, “Risk Characterization Handbook,” US Environmental Protection Agency, Washington DC, 2000. http://www.epa.gov/spc/pdfs/rchandbk.pdf
[22] L. C. Chien, T. C. Hung, K. Y. Choang, C. Y. Yeh, P. J. Meng, M. J. Shieh and B. C. Ha, “Daily Intake of TBT, Cu, Zn, Cd and As for Fishermen in Taiwan,” Science of the Total Environment, Vol. 285, No. 1-3, 2002, pp. 177185. doi:10.1016/S0048-9697(01)00916-0
[23] EC. Commission Regulation N. 1881/2006, “Setting Maximum Levels of Certain Contaminants in Foodstuff,” Official Journal of the European Union, Legislation Series, Vol. 65, 2006, pp. 5-24.
[24] M. Vinceti, T. Maraldi, M. Bergomi and C. Malagoli. “Risk of Chronic Low-Dose Selenium Overexposure in Humans: Insights from Epidemiology and Biochemistry,” Reviews on Environmental Health, Vol. 24, No. 3, 2009, pp. 231-248. doi:10.1515/REVEH.2009.24.3.231
[25] NRC, “Commitee on Toxicology. Arsenic in Drinking Water,” The National Academic Press, Washinton DC, 2001. http://www7.nationalacademies.org/ocga/testimony/arsenic_in_drinking_water.asp
[26] V. Sirot, T. Guerin, J. L. Volatier and J. C. Leblanc, “Dietary Exposure and Biomarkers of Arsenic in Consumers of Fish and Shellfish from France,” Science of the Total Environment, Vol. 407, No. 6, 2009, pp. 1875-1885. doi:10.1016/j.scitotenv.2008.11.050
[27] M. M. Wu, T. L. Kuo, Y. H. Hwang and C. J. Chen. “Dose-Response Relation between Arsenic Concentration in Well Water and Mortality from Cancers and Vascular Diseases,” American Journal of Epidemiology, Vol. 130, No. 6, 1989, pp. 1123-1132.
[28] C. J. Chen, C. W. Chen, M. M. Wu and T. L. Kuo, “Cancer Potential in Liver, Lung, Bladder and Kidney Due to Ingested Inorganic Arsenic in Drinking Water,” British Journal of Cancer, Vol. 66, No. 5, 1992, pp. 888-892. doi:10.1038/bjc.1992.380
[29] A. H. Smith, C. Hopenhayn-Rich, M. N. Bates, H. M. Goeden, I. Hertz-Picciotto, H. M. Duggan, R. Wood, M. J. Kosnett and M. T. Smith, “Cancer Risks from Arsenic in Drinking Water,” Environmental Health Perspectives, Vol. 97, 1992, pp. 259-267. doi:10.1289/ehp.9297259
[30] C. O. Abernathy, Y. P. Liu, D. Longfellow, H. V. Aposhian, B. Beck, B. Fowler, R. Goyer, R. Menzer, T. Rossman, C. Thompson and M. Waalkes, “Arsenic: Health Effects, Mechanisms of Actions, and Research Issues,” Environmental Health Perspectives, Vol. 107, No. 7, 1999, pp. 593-597. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566656/ doi:10.1289/ehp.99107593

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