Mortal neutropenic enterocolitis in acute lymphoblastic leukemia


Neutropenic enterocolitis (NE) or typhlitis is a serious complication of anticancer therapy, especially in he- matological malignancies. We describe a case of acute lymphoid leukemia presenting the early onset of a syndrome with the clinical features and specific radiological findings of NE during the neutropenic phase.

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Elcioglu, O. , Ozkok, A. , Akpinar, T. and Kucukkaya, R. (2013) Mortal neutropenic enterocolitis in acute lymphoblastic leukemia. Open Journal of Internal Medicine, 3, 53-54. doi: 10.4236/ojim.2013.32012.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Wagner, M.L., Rosenberg, H.S., Fernbach, D.J. and Singleton, E.B. (1970) Typhlitis a complication of leukemia in childhood. American Journal of Roentgenology, 109, 341-350. doi:10.2214/ajr.109.2.341
[2] Gorschluter, M., Glasmacher, A., Hahn, C., Leutner, C., Marklein, G., Remig, J., Schmidt-Wolf, I.G. and Sauerbruch, T. (2001) Severe abdominal infection in neutropenic patients. Cancer Investigation, 19, 669-677. doi:10.1081/CNV-100106141
[3] Tjon, A., Tham, R.T., Vlasveld, L.T. and Willemze, R. (1990) Gastrointestinal complications of cytosine-arabinoside chemotherapy: Findings on plain abdominal radiographs. American Journal of Roentgenology, 154, 95-98. doi:10.2214/ajr.154.1.2104733
[4] Gorschluter, M., Mey, U., Strehl, J., Ziske, C., Schepke, M., Schmidt-Wolf, I.G., Sauerbruch, T. and Glasmacher, A. (2005) Neutropenic enterocolitis in adults: Systematic analysis of evidence quality. European Journal of Haematology, 75, 1-13. doi:10.1111/j.1600-0609.2005.00442.x
[5] Cartoni, C., Dragoni, F., Micozzi, A., Pescarmona, E., Mecarocci, S., Chiletti, P., Petti, M.C., Meloni, G. and Mandelli, F. (2001) Neutropenic enterocolitis in patients with acute leukemia: Prognostic significance of bowel wall thickening detected by ultrasonography. Journal of Clinical Oncology, 19, 756-761.
[6] Davila, M.L. (2006) Neutropenic enterocolitis. Current Opinion in Gastroenterology, 22, 44-47.
[7] Cardona, A.F., Ramos, P.L. and Casasbuenas, A. (2005) From case reports to systematic reviews in neutropenic enterocolitis. European Journal of Haematology, 75, 445-446. doi:10.1111/j.1600-0609.2005.00544.x
[8] Gomez, L., Martino, R. and Rolston, K.V. (1998) Neutropenic enterocolitis: Spectrum of the disease and comparison of definite and possible cases. Journal of Clinical Investigation, 27, 695-699.

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