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Research of Quality Standards for Stachydrine Hydrochloride in Chinese Medicine TJF Granule

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DOI: 10.4236/pp.2013.43040    2,836 Downloads   5,098 Views  

ABSTRACT

A high-performance liquid chromatographic method was applied to the determination of stachydrine hydrochloride concentration in TJF granule (Chinese name: Tiao-Jing-Fang), using a mobile phase of methanol-acetonitrile (50:50, v/v) by the Agilent Kromasi NH2 column (250 mm × 4.6 mm, 5 μm, S/N: 22N25110). Detection wavelength was 201 nm. The result revealed good linearity of stachydrine hydrochloride and was obtained within the range of 0.20 - 1.98 μg/mL (R = 0.9995). The average recovery was 97.01%; the relative standard deviation (RSD) was 0.19%. To the best of our knowledge, this is the first report dedicated to the determination of stachydrine hydrochloride by the evaporative light scattering detector-high-performance liquid chromatographic (ELSD-HPLC) method.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Y. Lu, W. Yu, P. Shen, T. Khoo and C. Wiart, "Research of Quality Standards for Stachydrine Hydrochloride in Chinese Medicine TJF Granule," Pharmacology & Pharmacy, Vol. 4 No. 3, 2013, pp. 277-282. doi: 10.4236/pp.2013.43040.

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