Protective effects of polar lipids and redox-active compounds from marine organisms at modeling of hyperlipidemia and diabetes

Abstract


Cardiovascular diseases and diabetes mellitus are leading causes of mortality in modern society. The search for a novel effective remedy represents an important task for modern medicine. A total mixture of phospho- and glycolipids from sea macrophytes Sargassum pallidum, Ulva fenestrata, Zostera marina was separated and the fatty acid composition was determined. The biological activity of the mixtures of polar lipids and natural redox-active compounds (echinochrome A from the flat sea urchin Scaphechinus mirabilis and a polyphenolic complex from the sea grass Zostera marina) was studied under conditions of impairments of carbohydrate and lipid metabolism. Doses and compositions of mixtures of pola lipids and redox-active compounds possessing high corrective activity were optimized in mice with the experimental model of hyperlipidemia and diabetes. Based on these results possible mechanisms of the effects of polar lipids containing various polyunsaturated fatty acids and the investigated redox-active compounds (echinochrome A, rosmarinic acid, luteolin and its sulphate conjugates) have been proposed. The developed compositions may be used for creation of new biologically active additives and remedies.


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Popov, A. and Krivoshapko, O. (2013) Protective effects of polar lipids and redox-active compounds from marine organisms at modeling of hyperlipidemia and diabetes. Journal of Biomedical Science and Engineering, 6, 543-550. doi: 10.4236/jbise.2013.65069.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Calder, P.C. (2012) Long-chain fatty acids and inflammation. Proceedings of the Nutrition Society, 71, 284-289. doi:10.1017/S0029665112000067
[2] Bays, H.E., Goldberg, R.B., Truitt, K.E. and Jones, M.R. (2008) Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: Glucose and lipid effects. Archives of Internal Medicine, 168, 1975-1983. doi:10.1001/archinte.168.18.1975
[3] Krivoshapko, O.N., Popov, A.M. and Artyukov, A.A. (2011) Peculiarities of the corrective effects of polar lipids and bioantioxidants from sea hydrobionts in impairments of lipid and carbohydrate metabolism. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 5, 152-157. doi:10.1134/S1990750811020053
[4] Popov, A.M., Krivoshapko, O.N. and Artyukov, A.A. (2012) Mechanisms of the protective pharmacological activity of flavonoids. Journal of Biopharmaceuticals, 4, 27-41.
[5] Lebedev, A.V., Ivanova, M.V. and Levitsky, D.O. (2008) Iron chelators and free radical scavengers in naturally occurring polyhydroxylated 1,4-naphthoquinones. Hemoglobin, 32, 79-165. doi:10.1080/03630260701700017
[6] Mueller, M., Lukas, B., Novak, J., Simoncini, T., Genazzani, A.R. and Jungbauer, A. (2008) Oregano: A source for peroxisome proliferator-activated receptor gamma antagonists. Journal of Agricultural and Food Chemistry, 56, 11621-11630. doi:10.1021/jf802298w
[7] Ding, L., Jin, D. and Chen, X. (2009) Luteolin enhances insulin sensitivity via activation of PPARγ transcriptional activity in adipocytes. Journal of Nutritional Biochemistry, 21, 941-947. doi:10.1016/j.jnutbio.2009.07.009
[8] Barbier, O., Torra, I.P., Duguay, Y., Blanquart, C., Fruchart, J.C., Glineur, C. and Staels, B. (2002) Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 22, 717-722. doi:10.1161/01.ATV.0000015598.86369.04
[9] Folch, J., Lees, M. and Sloane Stanley, G.H. (1957) A simple method for the isolation and purification of total lipides from animal tissues. Journal of Biological Chemistry, 226, 497-509.
[10] Sanina, N.M., Goncharova, S.N. and Kostetsky, E.Y. (2004) Fatty acid composition of individual polar lipid classes from marine macrophytes. Phytochemistry, 65, 721-730. doi:10.1016/j.phytochem.2004.01.013
[11] Popov A.M., Artyukov A.A., Krivoshapko O.N., Krilova N.V. and Kozlovskaya E.P. (2011) Remedy possessing antioxidant, cardioprotective, antiinflametory, hepatoprotective, antidiabetes, antitumor and antiviral effects. Russian Federation Patent No. 2432959.
[12] Nishibori, K. (1961) Isolation of echinochrome A from the spines of the sea urchin, Stomopneustes variolaris (Lamarck). Nature, 192, 1293-1294. doi:10.1038/1921293a0
[13] Yanai, H., Tomono, Y., Ito, K., Furutani, N., Yoshida, H., and Tada, N. (2007) Diacylglycerol oil for the metabolic syndrome. Nutrition Journal, 6, 43-57. doi:10.1186/1475-2891-6-43
[14] Baylin, A., Kim, M.K., Donovan-Palmer, A., Siles, X., Dougherty, L., Tocco, P. and Campos, H. (2005) Fasting whole blood as a biomarker of essential fatty acid intake in epidemiologic studies: Comparison with adipose tissue and plasma. American Journal of Epidemiology, 162, 373-381. doi:10.1093/aje/kwi213
[15] Calder, P.C. (2009) Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale. Biochimie, 91, 791-795. doi:10.1016/j.biochi.2009.01.008
[16] Perry, G. and Epel, D. (1981) Ca2+-stimulated production of H2O2 from naphtoquinone oxidation in Arbacia eggs. Experimental Cell Research, 134, 65-72. doi:10.1016/0014-4827(81)90463-8
[17] Veal, E.A., Day, A.M. and Morgan, B.A. (2007) Hydrogen peroxide sensing and signaling. Molecular Cell, 26, 1-14. doi:10.1016/j.molcel.2007.03.016
[18] Lebedev A.V., Ivanova M.V. and Levitsky D.O. (2005) Echinochrome, a naturally occurring iron chelator and free radical scavenger in artificial and natural membrane systems. Life Sciences, 76, 863-875. doi:10.1016/j.lfs.2004.10.007
[19] Artyukov А.А., Popov А.М., Tsybulsky A.V., Krivoshapko O.N. and Polyakova N.V. (2012) Pharmacological activity echinochrome а singly and consisting of BAA “Timarin”. Biomeditsinskaia Khimiia, 59, 281-290.
[20] Jones, D.P. (2010) Redox sensing: Orthogonal control in cell cycle and apoptosis signalling. Journal of Internal Medicine, 268, 432-448. doi:10.1111/j.1365-2796.2010.02268.x
[21] Kim, H.P., Son, K.H., Chang, H.W. and Kang, S.S. (2004) Anti-inflammatory plant flavonoids and cellular action mechanisms. Journal of Pharmacological Sciences, 96, 229-245. doi:10.1254/jphs.CRJ04003X

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