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Myeloid sarcoma as a differential diagnosis of small bowel obstruction

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DOI: 10.4236/crcm.2013.22047    3,061 Downloads   4,531 Views  


We are presenting the case of a 42-year-old  male patient, who was hospitalized due to an acute small bowel obstruction caused by a tissue mass of the mesentery. The patient reported that he had a history of a testicular tumour. For therapy of intestinal obstruction as well as for diagnostic reasons we decided to perform  an explorative laparotomy. On histopathological examination the immunohistological staining was positive for myeloperoxidase (MPO) and KP-1 (CD68). Staining was slightly positive for Bcl-2, CD117, CD34, but negative for CD3, CD4, CD5, CD8, CD20, CD30, CD79, Bcl-6 and S-100. This leads to the diagnosis of a myeloid sarcoma. After recovery from surgery and chemotherapy, allogenic bone marrow transplantation was performed. Most intestinal obstructions are caused by postoperative adhesions or hernias and only in rare cases caused by a myeloid sarcoma.

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The authors declare no conflicts of interest.

Cite this paper

Kettler, B. , Abbas, M. , Ringe, B. , Hambach, L. , Klempnauer, J. , Winkler, M. , Kreipe, H. and Emmanouilidis, N. (2013) Myeloid sarcoma as a differential diagnosis of small bowel obstruction. Case Reports in Clinical Medicine, 2, 173-176. doi: 10.4236/crcm.2013.22047.


[1] Antic, D., Elezovic, I., Bogdanovic, A., Vukovic, N.S., Pavlovic, A., Jovanovic, M.P., et al. (2010) Isolated myeloid sarcoma of the gastrointestinal tract. Internal Medicine Journal, 49, 853-856. doi:10.2169/internalmedicine.49.2874
[2] Sivan-Hoffmann, R., Waksman, I., Cohen, H.I. and Eitan, A. (2011) Small bowel obstruction as a presenting sign of granulocytic sarcoma. The Israel Medical Association Journal, 13, 507-509.
[3] Kohl, S.K. and Aoun, P. (2006) Granulocytic sarcoma of the small intestine. Archives of Pathology & Laboratory Medicine, 130, 1570-1574.
[4] Kumar, B., Bommana, V., Irani, F., Kasmani, R., Mian, A. and Mahajan, K. (2009) An uncommon case of small bowel obstruction: Isolated primary granulocytic sarcoma. QJM: An International Journal of Medicine, 102, 491-493. doi:10.1093/qjmed/hcp051
[5] Corbacioglu, A., Scholl, C., Schlenk, R.F., Eiwen, K., Du, J., Bullinger, L., Fröhling, S., et al. (2010) Prognostic Impact of Minimal Residual Disease in CBFB-MYH11-Positive Acute Myeloid Leukemia. Journal of Clinical Oncology, 28, 3724-3729. doi:10.1200/JCO.2010.28.6468
[6] Sarraf-Yazdi, S. and Shapiro, M.L. (2010) Small bowel obstruction: The eternal dilemma of when to intervene. Scandinavian Journal of Surgery, 99, 78-80.
[7] Yamauchi, K. and Yasuda, M. (2002) Comparison in treatments of nonleukemic granulocytic sarcoma. Report of two cases and review of 72 cases in the literature. American Cancer Society, 94, 1739-1746.
[8] Tsimberidou, A.M., Kantarjian, H.M., Estey, E., Cortes, J.E., Verstovsek, S., Faderl, S., et al. (2003) Outcome in patients with nonleukemic granulocytic sarcoma treated with chemotherapy with or without radiotherapy. Leukemia, 17, 1100-1103. doi:10.1038/sj.leu.2402958
[9] Tsimberidou, A.M., Katarjian, H.M., Wen, S., Keating, M.J., Susan, B., Brandt, M., Pierce, S., Freireich, E.J., Mederiros, J.M. and Estey, E. (2008) Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia. Cancer, 113, 1370-1378.

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