Clear cell carcinoma of salivary gland type presenting as an endotracheal polypoid tumor
Kazuhiro Tabata, Michiyo Higashi, Shinichi Kitajima, Ikumi Kitazono, Tsubasa Hiraki, Tsunayuki Otsuka, Masaya Aoki, Kazuhiro Wakita, Hirofumi Nakayama, Suguru Yonezawa, Junya Fukuoka
Department of General Thoracic Surgery, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan.
Department of Human Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Department of Pathology, Kagoshima University Hospital, Kagoshima, Japan.
Department of Pathology, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Laboratory of Pathology, Nagasaki University Hospital, Nagasaki, Japan;.
DOI: 10.4236/crcm.2013.22043   PDF   HTML     3,218 Downloads   4,819 Views  


A 66-year-old woman presented with a 2-year history of asthma has progression of dyspnea within a week, and a computed tomography (CT) revealed an endotracheal tumor at level of aortic arch. The resected tumor, measured by 18 × 12 × 10 mm, has histologically malignant features including frank invasion with desmoplastic stroma and foci of necrosis. Presence of glycogen and mucin was confirmed by periodic acid-Schiff (PAS) and diastase PAS staining. Immunohistochemically, the tumor cells were diffusely positive for cytokeratin (CK) 7 and AE1/3, focally positive for CK5/6 and CK14, but negative for CK20. Thyroid transcription factor-1 (TTF-1), Napsin A, and SP-A, indicating lung parenchymal origin were all negative. Other muscular markers, neuroendocrine markers, renal cell carcinoma markers, and markers related to perivascular epithelioid cell tumors were all negative. Postoperative systemic examination suggests no primary tumor outside the lung. The follow up was excellent being recurrence free for 14 months in spite of the positive surgical margin by the tumor cells. This is a first report  of rare neoplasm, clear cell carcinoma of salivary gland type, presenting as an endotracheal mass.

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Tabata, K. , Higashi, M. , Kitajima, S. , Kitazono, I. , Hiraki, T. , Otsuka, T. , Aoki, M. , Wakita, K. , Nakayama, H. , Yonezawa, S. and Fukuoka, J. (2013) Clear cell carcinoma of salivary gland type presenting as an endotracheal polypoid tumor. Case Reports in Clinical Medicine, 2, 159-162. doi: 10.4236/crcm.2013.22043.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Moran, C.A. (1995) Primary salivary gland-type tumors of the lung. Seminars in Diagnostic Pathology, 12, 106-122.
[2] Heitmiller, R.F., Mathisen, D.J., Ferry, J.A., Mark, E.J. and Grillo, H.C. (1989) Mucoepidermoid lung tumors. Annals of Thoracic Surgery, 47, 394-399. doi:10.1016/0003-4975(89)90380-9
[3] Katzenstein, A.L., Prioleau, P.G. and Askin, F.B. (1980) The histologic spectrum and significance of clear-cell change in lung carcinoma. Cancer, 45, 943-947. doi:10.1002/1097-0142(19800301)45:5<943::AID-CNCR2820450518>3.0.CO;2-7
[4] Travis, W.D., Blambilla, E., Kornrad Muller-Hermelink, H.K. and Harris, C.C. (2004) WHO classification of tumours. Pathology and genetics of tumours of the lung, pleura, thymus and heart. IARC Press, Lyon.
[5] Whithaus, K., Fukuoka, J., Prihoda, T.J. and Jagirdar, J. (2012) Evaluation of napsin A, cytokeratin 5/6, p63, and thyroid transcription factor 1 in adenocarcinoma versus squamous cell carcinoma of the lung. Archives of Pathology & Laboratory Medicine, 136, 155-162. doi:10.5858/arpa.2011-0232-OA
[6] Barnes, L., Eveson, J.W., Reichart, P. and Sidransky, D. (2005) World Health Organization classification of tumours. Vol. 9: Pathology and genetics of tumours of the head and neck. IARC Press, Lyon.
[7] Yang, S., Zhang, J., Chen, X., Wang, L. and Xie, F. (2008) Clear cell carcinoma, not otherwise specified, of salivary glands: A clinicopathologic study of 4 cases and review of the literature. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics, 106, 712-720. doi:10.1016/j.tripleo.2008.04.016
[8] Wang, B., Brandwein, M., Gordon, R., Robinson, R., Urken, M. and Zarbo, R.J. (2002) Primary salivary clear cell tumors—A diagnostic approach a clinicopathologic and immunohistochemical study of 20 patients with clear cell carcinoma, clear cell myoepithelial carcinoma, and epithelial-myoepithelial carcinoma. Archives of Pathology & Laboratory Medicine, 126, 676-685.
[9] Iyoda, A., Hiroshima, K., Toyozaki, T., Tsukamoto, Y., Haga, Y., Fujisawa, T. and Ohwada, H. (2000) Clear cell adenocarcinoma with endobronchial polypoid growth. Pathology International, 50, 979-983. doi:10.1046/j.1440-1827.2000.01140.x

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