Theory of affinity maturation of antibodies

DOI: 10.4236/abb.2013.44A010   PDF   HTML   XML   3,898 Downloads   6,596 Views   Citations

Abstract

Based on the theory of long distance interaction between antibodies and antigens we developed a theory of affinity maturation of antibodies that is based on longitudinale electric waves. Early stage antibodies show a wide frequency spectrum for antigens and are polyspecific. After affinity maturation the antibody shows a very narrow band spectrum, the antibodies become monospecific. The feedback between antibody and antibody producing cell is done via messenger molecules that are also communicating with help of longitudinal electric waves. These messenger molecules transfer information from antibody arms and are informing cells whether the epitopes are switched on or off. The folding of antibody is done via eigen frequency resonances.

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Riss, U. (2013) Theory of affinity maturation of antibodies. Advances in Bioscience and Biotechnology, 4, 67-72. doi: 10.4236/abb.2013.44A010.

Conflicts of Interest

The authors declare no conflicts of interest.

References

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