Susceptibility of Staphylococcus aureus Isolates Causing Bloodstream Infection to the Antimicrobial Peptide LL-37

Abstract Full-Text HTML XML Download Download as PDF (Size:226KB) PP. 80-83
DOI: 10.4236/ojmm.2013.31012    2,797 Downloads   4,983 Views   Citations


Both bacterial and host factors contribute to complicated bloodstream infection (BSI) caused by Staphylococcus aureus including methicillin-resistant S. aureus (MRSA). One bacterial factor that may affect the persistence of S. aureus in complicated BSI is reduced susceptibility to the innate immune defence peptide LL-37. LL-37 susceptibility among S. aureus isolates causing uncomplicated and complicated BSI was investigated. Following incubation with 2.5 μg/ml LL-37 for 1 h, the mean percentage survival was 67.6% and 74.9% for isolates causing uncomplicated and complicated BSI, respectively. Reduced LL-37 susceptibility may contribute to the persistence of S. aureus in complicated BSI.

Cite this paper

S. McNicholaswhj, H. Humphreys and D. Hughes, "Susceptibility of Staphylococcus aureus Isolates Causing Bloodstream Infection to the Antimicrobial Peptide LL-37," Open Journal of Medical Microbiology, Vol. 3 No. 1, 2013, pp. 80-83. doi: 10.4236/ojmm.2013.31012.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] J. D. Heilborn, M. F. Nilsson, G. Kratz, G. Weber, O. Sorensen, N. Borregaard and M. Stahle-Backdahl, “The Cathelicidin Anti-Microbial Peptide LL-37 Is Involved in Re-Epithelialization of Human Skin Wounds and Is Lacking in Chronic Ulcer Epithelium,” Journal of Investigative Dermatology, Vol. 120, No. 3, 2003, pp. 379-389. doi:10.1046/j.1523-1747.2003.12069.x
[2] A. R. Koczulla and R. Bals, “Antimicrobial Peptides: Current Status and Therapeutic Potential,” Drugs, Vol. 63, No. 4, 2003, pp. 389-406. doi:10.2165/00003495-200363040-00005
[3] J. Overhage, A. Campisano, M. Bains, E. C. Torfs, B. H. Rehm and R. E. Hancock, “Human Host Defense Peptide LL-37 Prevents Bacterial Biofilm Formation,” Infection and Immunity, Vol. 76, No. 9, 2008, pp. 4176-4182. doi:10.1128/IAI.00318-08
[4] I. Fedtke, F. Gotz and A. Peschel, “Bacterial Evasion of Innate Host Defenses—The Staphylococcus aureus Lesson,” International Journal of Medical Microbiology, Vol. 294, No. 2-3, 2004, pp. 189-194. doi:10.1016/j.ijmm.2004.06.016
[5] H. Komatsuzawa, K. Ouhara, S. Yamada, T. Fujiwara, K. Sayama, K. Hashimoto and M. Sugai, “Innate Defences against Methicillin-Resistant Staphylococcus aureus (MRSA) Infection,” Journal of Pathology, Vol. 208, No. 2, 2006, pp. 249-260. doi:10.1002/path.1898
[6] M. Sieprawska-Lupa, P. Mydel, K. Krawczyk, K. Wojcik, M. Puklo, B. Lupa, P. Suder, J. Silberring, M. Reed, J. Pohl, W. Shafer, F. McAleese, T. Foster, J. Travis and J. Potempa, “Degradation of Human Antimicrobial Peptide LL-37 by Staphylococcus aureus-Derived Proteinases,” Antimicrobial Agents and Chemotherapy, Vol. 48, No. 12, 2004, pp. 4673-4679. doi:10.1128/AAC.48.12.4673-4679.2004
[7] S. McNicholas, A. C. Shore, D. C. Coleman, H. Humphreys and D. F. Hughes, “DNA Microarray Genotyping and Virulence and Antimicrobial Resistance Gene Profiling of Methicillin-Resistant Staphylococcus aureus Bloodstream Isolates from Renal Patients,” Journal of Clinical Microbiology, Vol. 49, No. 12, 2011, pp. 4349-4351. doi:10.1128/JCM.05017-11
[8] K. Ouhara, H. Komatsuzawa, T. Kawai, H. Nishi, T. Fujiwara, Y. Fujiue, M. Kuwabara, K. Sayama, K. Hashimoto and M. Sugai, “Increased Resistance to Cationic Antimicrobial Peptide LL-37 in Methicillin-Resistant Strains of Staphylococcus aureus,” Journal of Antimicrobial Chemotherapy, Vol. 61, No. 6, 2008, pp. 1266-1269. doi:10.1093/jac/dkn106
[9] K. Midorikawa, K. Ouhara, H. Komatsuzawa, T. Kawai, S. Yamada, T. Fujiwara, K. Yamazaki, K. Sayama, M. A. Taubman, H. Kurihara, K. Hashimoto and M. Sugai, “Staphylococcus aureus Susceptibility to Innate Antimicrobial Peptides, Beta-Defensins and CAP18, Expressed by Human Keratinocytes,” Infection and Immunity, Vol. 71, No. 7, 2003, pp. 3730-3739. doi:10.1128/IAI.71.7.3730-3739.2003
[10] T. J. Foster, “Immune Evasion by Staphylococci,” Nature Reviews Microbiology, Vol. 3, No. 12, 2005, pp. 948-958. doi:10.1038/nrmicro1289
[11] S. H. Rooijakkers, K. P. van Kessel and J. A. van Strijp, “Staphylococcal Innate Immune Evasion,” Trends in Microbiology, Vol. 13, No. 12, 2005, pp. 596-601. doi:10.1016/j.tim.2005.10.002

comments powered by Disqus

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.