Susceptibility of Staphylococcus aureus Isolates Causing Bloodstream Infection to the Antimicrobial Peptide LL-37

DOI: 10.4236/ojmm.2013.31012   PDF   HTML   XML   2,911 Downloads   5,090 Views   Citations

Abstract

Both bacterial and host factors contribute to complicated bloodstream infection (BSI) caused by Staphylococcus aureus including methicillin-resistant S. aureus (MRSA). One bacterial factor that may affect the persistence of S. aureus in complicated BSI is reduced susceptibility to the innate immune defence peptide LL-37. LL-37 susceptibility among S. aureus isolates causing uncomplicated and complicated BSI was investigated. Following incubation with 2.5 μg/ml LL-37 for 1 h, the mean percentage survival was 67.6% and 74.9% for isolates causing uncomplicated and complicated BSI, respectively. Reduced LL-37 susceptibility may contribute to the persistence of S. aureus in complicated BSI.

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S. McNicholaswhj, H. Humphreys and D. Hughes, "Susceptibility of Staphylococcus aureus Isolates Causing Bloodstream Infection to the Antimicrobial Peptide LL-37," Open Journal of Medical Microbiology, Vol. 3 No. 1, 2013, pp. 80-83. doi: 10.4236/ojmm.2013.31012.

Conflicts of Interest

The authors declare no conflicts of interest.

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