Oncomodulin and macrophages derived factors in pancreas injury and development paradigms

Joël Fleury Djoba Siawaya, Carmen Capito, Raphael Scharfmann

Centre de Recherche “Croissance et Signalisation”, Inserm Unité-845, Faculté de Médecine Paris 5, Paris, France;.
Centre de Recherche “Croissance et Signalisation”, Inserm Unité-845, Faculté de Médecine Paris 5, Paris, France;Laboratoire National de Santé Publique, Unité de Recherche, Libreville, Gabon.

DOI: 10.4236/mri.2013.21001                

Abstract

Prior studies in the optic nerve injury paradigm showed con?icting data regarding production and signi?cance of the Ca²⁺-binding protein oncomodulin (OCM). Some have shown its potentaxon-regenerative or-growth attribute, where other showed little to no effect. We show here that pancreas inflammation lead to macrophages infiltration that produce OCM and inflamed tissues that express OCM receptorsin vivo. In culture OCM has a cytostatic effect on embryonic pancreas explants. Secretory products of zymosan activated macrophages are cytotoxic and factors derived from non-activated macrophages seem to promote pancreas development. It is our view that OCM is involved in protective injury response that allows through metabolism slowing sublethally injured cells to undergo recovery.

Keywords

Macrophages; Oncomodulin; Inflammation; Pancreas

Conflicts of Interest

The authors declare no conflicts of interest.

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